New pyrimidines and triazolopyrimidines as antiproliferative and antioxidants with cyclooxygenase-1/2 inhibitory potential.

Cyclooxygenase-2 (COX-2) inhibition and scavenging-free radicals are important targets in cancer treatment. Sulfanylpyrimidines and triazolopyrimidines were synthesized and evaluated as anticancer and antioxidant COX-1/2 inhibitors. Compound showed the same growth inhibitory activity as 5-fluorouracil against MCF-7. Compound displayed broad-spectrum anticancer activity against the four tested cancer cell lines. Compounds and were found to be more active antioxidants than trolox. Compounds and revealed high COX-2 inhibitory activity and selectivity, which was confirmed by docking studies. Compound could be considered as promising anticancer and antioxidant structural lead with COX-2 inhibition that deserve further derivatization and investigation.