Neurorehabilitation Unit and INSPE-Institute of Experimental Neurology, San Raffaele Hospital, Milan, Italy/Vita-Salute San Raffaele University, Milan, Italy.
Neurorehabilitation Unit and INSPE-Institute of Experimental Neurology, San Raffaele Hospital, Milan, Italy.
Mult Scler. 2019 Sep;25(10):1363-1371. doi: 10.1177/1352458519865734.
Although the number of disease-modifying treatments for people with multiple sclerosis (pwMS) has meaningfully increased in the past years, targeting repair or compensation for central nervous system damage associated with the disease process remains an important clinical goal. With this aim, neurorehabilitation is a powerful approach targeting central nervous system plasticity. Another driver of brain plasticity is non-invasive brain stimulation (NIBS), receiving recent attention in neurology, particularly for its potential synergy with neurorehabilitation and as add-on treatment for several neurological conditions, from pain to fatigue to sensorimotor and cognitive deficits. In this review, we will resume the evidence exploring the neurobiological basis of NIBS and its applications to MS-related conditions.
虽然近年来多发性硬化症（pwMS）患者的疾病修正治疗数量显著增加，但针对与疾病过程相关的中枢神经系统损伤的修复或代偿仍然是一个重要的临床目标。为此，神经康复是一种针对中枢神经系统可塑性的强大方法。大脑可塑性的另一个驱动因素是非侵入性脑刺激（NIBS），它在神经病学领域受到了最近的关注，特别是因为它有可能与神经康复协同作用，并作为几种神经系统疾病的附加治疗方法，从疼痛到疲劳，再到感觉运动和认知缺陷。在这篇综述中，我们将回顾探索 NIBS 的神经生物学基础及其在 MS 相关疾病中的应用的证据。
