Kueh Y K, Koh D R, Chan T B, Han P
Department of Medicine, National University Hospital, Singapore.
Ann Acad Med Singap. 1988 Oct;17(4):589-94.
The management of patients with Factor VIIIC inhibitor is frequently a therapeutic challenge. Treatment is often individualized. We describe 3 patients, nonhaemophilic adults, with bleeding diatheses caused by a circulating inhibitor to Factor VIIIC. One patient had long standing rheumatoid arthritis. The other two did not have any apparent underlying disease, although one of them had an antecedent antecedent phenylbutazone injection for arthralgias. Prednisolone was prescribed for two patients which resulted in rapid clinical improvement and the eventual normalization of Factor VIIIC activity. The role and rationale of immunosuppressive therapy in Factor VIIIC inhibitor is reviewed.
伴有Ⅷ因子抑制物的患者的管理常常是一项治疗挑战。治疗通常是个体化的。我们描述了3例非血友病成年患者，他们因循环中的Ⅷ因子抑制物而出现出血倾向。1例患者患有长期类风湿关节炎。另外2例没有任何明显的基础疾病，尽管其中1例曾因关节痛注射过保泰松。2例患者使用了泼尼松龙，临床症状迅速改善，Ⅷ因子活性最终恢复正常。本文综述了免疫抑制治疗在Ⅷ因子抑制物中的作用及理论依据。
