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与 1 型糖尿病成人血糖控制相关的因素:一项基于登记的分析,包括来自挪威 34 个中心的 7601 个人。

Factors associated with glycaemic control in adults with Type 1 diabetes: a registry-based analysis including 7601 individuals from 34 centres in Norway.

机构信息

Department of Medicine, Stavanger University Hospital, Stavanger, Norway.

Norwegian Organisation for Quality Improvement of Laboratory Examinations (Noklus), Haraldsplass Deaconess Hospital, Bergen, Norway.

出版信息

Diabet Med. 2020 May;37(5):828-837. doi: 10.1111/dme.14123. Epub 2019 Oct 18.

DOI:10.1111/dme.14123
PMID:31469928
Abstract

AIMS

To use data from the Norwegian Diabetes Registry for Adults and Statistics Norway to assess factors associated with glycaemic control in type 1 diabetes.

METHODS

The analyses included all individuals aged ≥18 years who had a type 1 diabetes duration of >2 years and a recorded value in the registry between 2013 and 2015 (n=7601). Predicted mean HbA levels for subgroups of participants were assessed using linear regression analysis.

RESULTS

Young age (18-25 years), low education levels, smoking, living alone, exercising infrequently, monitoring glucose infrequently, high insulin requirements, low frequency of symptomatic hypoglycaemia, history of ketoacidosis and a BMI <18.5 kg/m were associated with a 2-12-mmol/mol (0.2-1.1%) higher HbA level. Those with 10-15 years of diabetes duration had 5-mmol/mol (0.5%) higher HbA level than those who had a diabetes duration of 2-5 years. Sex, participation (ever) in a diabetes education course, or ever experiencing serious hypoglycaemia were not associated with glycaemic control.

CONCLUSIONS

We present representative national data on factors that were associated with glycaemic control. A better understanding and awareness of these factors, together with technological advances in diabetes management, could lead to more personalized management strategies, better glycaemic control and a lower risk of diabetes complications.

摘要

目的

利用挪威成人糖尿病登记处和挪威统计局的数据,评估与 1 型糖尿病患者血糖控制相关的因素。

方法

本分析纳入了年龄≥18 岁、1 型糖尿病病程>2 年且 2013 年至 2015 年在登记处有记录的所有患者(n=7601)。采用线性回归分析评估各亚组参与者的预测平均 HbA1c 水平。

结果

年轻(18-25 岁)、教育程度低、吸烟、独居、运动不频繁、血糖监测不频繁、胰岛素需求量高、无症状性低血糖发作频率低、酮症酸中毒病史以及 BMI<18.5kg/m2 与 HbA1c 升高 2-12mmol/mol(0.2-1.1%)相关。病程 10-15 年的患者 HbA1c 比病程 2-5 年的患者高 5mmol/mol(0.5%)。性别、是否参加过糖尿病教育课程或是否曾经历严重低血糖均与血糖控制无关。

结论

本研究提供了与血糖控制相关因素的代表性全国数据。更好地了解和认识这些因素,以及糖尿病管理方面的技术进步,可能会导致更个性化的管理策略、更好的血糖控制和降低糖尿病并发症风险。

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