每周进行 5 天或 2 天相同运动量时，低血糖时间相当：1 型糖尿病患者的随机交叉研究。
Time spent in hypoglycemia is comparable when the same amount of exercise is performed 5 or 2 days weekly: a randomized crossover study in people with type 1 diabetes.
机构信息
Diabetes Technology, Steno Diabetes Center Copenhagen, Gentofte, Denmark
Danish Diabetes Academy, Odense, Syddanmark, Denmark.
出版信息
BMJ Open Diabetes Res Care. 2021 Jan;9(1). doi: 10.1136/bmjdrc-2020-001919.
INTRODUCTION
People with type 1 diabetes are recommended to exercise regularly. However, limited evidence exists on how frequency and duration of exercise affect the risk of hypoglycemia. The study aimed to compare the percentage of time spent in hypoglycemia between two 5-day periods with different frequency and duration of physical activity.
RESEARCH DESIGN AND METHODS
In this outpatient randomized crossover study, 26 participants aged 18-65 years with type 1 diabetes for ≥2 years and insulin pump use for ≥1 year were included. After a 7-day observation period, participants completed two 5-day intervention periods separated by a washout period of at least 14 days. One period included five exercise sessions on 5 consecutive days (5S), each consisting of 4 min of resistance training and 30 min of aerobic exercise. Another period included two exercise sessions on 2 days with at least 2 days in between (2S), each consisting of 10 min of resistance training and 75 min of aerobic exercise. During each period, participants performed in total 150 min of aerobic exercise and 20 min of resistance training and wore continuous glucose monitors (Dexcom G6) and accelerometers (ActiGraph wGT3X-BT).
RESULTS
Twenty insulin pump-treated adults (10 women) with type 1 diabetes completed the study. The baseline median (range) age was 48 (24-64) years, glycated hemoglobin 55 (44-66) mmol/mol, diabetes duration 24 (8-57) years, and body mass index 28.4 (22.3-35.8) kg/m. No differences were observed between 5S and 2S in the percentage (mean±SD) of time spent below 3.9 mmol/L (3.5%±2.8% vs 4.5%±4.2%, p=0.28), time spent in 3.9-10.0 mmol/L (65.3%±15.0% vs 68.5%±13.6%, p=0.31), time spent above 10.0 mmol/L (31.2%±16.4% vs 27.3%±14.5%, p=0.15), mean glucose (8.7±1.3 mmol/L vs 8.5±1.2 mmol/L, p=0.33) and glycemic variability (35.8%±5.3% vs 35.8%±6.6%, p=0.97).
CONCLUSIONS
Time spent in hypoglycemia was comparable between the two 5-day periods with different duration and frequency of physical activity.
TRIAL REGISTRATION NUMBER
NCT04089462.
简介
建议 1 型糖尿病患者定期进行运动。然而，关于运动频率和持续时间如何影响低血糖风险的证据有限。本研究旨在比较两种不同运动频率和持续时间的 5 天期间内低血糖发生时间的百分比。
研究设计和方法
在这项门诊随机交叉研究中，纳入了 26 名年龄在 18-65 岁、患有 1 型糖尿病至少 2 年且使用胰岛素泵至少 1 年的患者。在 7 天观察期后，参与者完成了两个 5 天的干预期，间隔至少 14 天的洗脱期。一个期间包括连续 5 天每天 5 次运动，每次运动包括 4 分钟的抗阻力训练和 30 分钟的有氧运动。另一个期间包括 2 天内进行 2 次运动，中间至少间隔 2 天，每次运动包括 10 分钟的抗阻力训练和 75 分钟的有氧运动。在每个期间，参与者总共进行 150 分钟的有氧运动和 20 分钟的抗阻力训练，并佩戴连续血糖监测仪（Dexcom G6）和加速度计（ActiGraph wGT3X-BT）。
结果
20 名接受胰岛素泵治疗的成年人（10 名女性）完成了这项研究。基线时的中位（范围）年龄为 48（24-64）岁，糖化血红蛋白 55（44-66）mmol/mol，糖尿病病程 24（8-57）年，体重指数 28.4（22.3-35.8）kg/m。5S 和 2S 之间在以下方面没有差异：血糖低于 3.9mmol/L 的时间百分比（均值±标准差）（4.5%±4.2% vs 4.5%±4.2%，p=0.28）、血糖在 3.9-10.0mmol/L 之间的时间百分比（65.3%±15.0% vs 68.5%±13.6%，p=0.31）、血糖高于 10.0mmol/L 的时间百分比（31.2%±16.4% vs 27.3%±14.5%，p=0.15）、平均血糖（8.7±1.3mmol/L vs 8.5±1.2mmol/L，p=0.33）和血糖变异性（35.8%±5.3% vs 35.8%±6.6%，p=0.97）。
结论
两种不同运动频率和持续时间的 5 天期间内，低血糖发生时间无差异。
临床试验注册号
NCT04089462。
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