Research and Innovation Technology, Nutraceutical Department, Labomar Research, 31036 Istrana, Italy.
Medical and Surgical Sciences Department, University of Bologna, 40138 Bologna, Italy.
Mar Drugs. 2019 Aug 29;17(9):508. doi: 10.3390/md17090508.
Astaxanthin is a carotenoid extracted from several seaweeds with ascertained therapeutic activity. With specific reference, astaxanthin is widely used in clinical practice to improve ocular tissue health and skin protection from UV ray damages. Despite its well-documented pleiotropic actions and demonstrated clinical efficacy, its bioavailability in humans is low and limited because of its hydrophobicity and poor dissolution in enteric fluids. Furthermore, astaxanthin is very unstable molecule and very sensitive to light exposure and thermal stress. Taken together, these pharmacological and chemical-physical features strongly limit pharmaceutical and nutraceutical development of astaxanthin-based products and as a consequence its full clinical usage. This work describes the preliminary in vitro investigation of sublingual absorption of astaxanthin through a novel ascorbyl palmitate (ASP) based nanoemulsion.
虾青素是一种从几种海藻中提取的类胡萝卜素，具有确定的治疗活性。具体来说，虾青素广泛应用于临床实践中，以改善眼组织健康和皮肤对紫外线损伤的保护。尽管虾青素具有广泛记载的多效作用和已证明的临床疗效，但由于其疏水性和在肠液中溶解不良，其在人体中的生物利用度较低且有限。此外，虾青素是一种非常不稳定的分子，对光暴露和热应激非常敏感。综上所述，这些药理学和理化特性极大地限制了基于虾青素的产品的药物和营养保健品的开发，因此也限制了其全面的临床应用。本工作描述了通过新型抗坏血酸棕榈酸酯（ASP）基纳米乳进行虾青素舌下吸收的初步体外研究。
