绿茶对大鼠体内阿莫西林胃肠道吸收的影响。
Effect of green tea on the gastrointestinal absorption of amoxicillin in rats.
机构信息
Department of Pharmacognosy, Faculty of Pharmacy, University of Szeged, Eötvös utca 6, Szeged, H-6720, Hungary.
Interdisciplinary Centre for Natural Products, University of Szeged, Eötvös utca 6, Szeged, H-6720, Hungary.
出版信息
BMC Pharmacol Toxicol. 2019 Aug 30;20(1):54. doi: 10.1186/s40360-019-0332-8.
BACKGROUND
The investigation of food-drug and plant-drug interactions has become increasingly important. In case of antibiotics, it is essential to achieve and maintain a plasma concentration sufficient for the antimicrobial action. Although, on theoretical basis, the interaction of polyphenols and antibiotics may be hypothesized, experimental data are lacking to assess its clinical relevance. The aim of our study was to assess the interaction between one of the most widely used antibiotics, amoxicillin, and green tea, the most frequently consumed drink with high polyphenol content.
METHODS
The effects of green tea on the plasma level of amoxicillin was studied in an in vivo experiment in rats. The plasma level of amoxicillin was monitored by LC-MS/MS for 240 min after oral administration. The polyphenol content of green tea was determined by the Folin-Ciocalteu method.
RESULTS
The peak plasma concentration of amoxicillin significantly decreased upon its co-administration with green tea, although the AUC of the antibiotic did not decrease significantly in the group treated with amoxicillin suspended in green tea.
CONCLUSIONS
Our results suggest a potentially relevant interaction between green tea and amoxicillin, worth being further studied in humans.
背景
食物-药物和植物-药物相互作用的研究变得越来越重要。对于抗生素而言，达到并维持足以发挥抗菌作用的血浆浓度是至关重要的。尽管从理论基础上推测，多酚和抗生素之间可能存在相互作用，但缺乏实验数据来评估其临床相关性。我们的研究旨在评估最广泛使用的抗生素之一——阿莫西林，与绿茶之间的相互作用，绿茶是最常饮用的含有高多酚类物质的饮品。
方法
我们通过在大鼠体内实验研究了绿茶对阿莫西林血浆水平的影响。在口服给药后 240 分钟内，通过 LC-MS/MS 监测阿莫西林的血浆水平。采用福林-肖卡法测定绿茶中的多酚含量。
结果
尽管在服用阿莫西林悬浮于绿茶中的组中，抗生素的 AUC 没有显著下降，但阿莫西林的血浆峰浓度在与绿茶同时给药时显著降低。
结论
我们的结果提示绿茶和阿莫西林之间可能存在潜在的相关相互作用，值得在人类中进一步研究。
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