Department of Pediatrics, University of Colorado, Aurora, Colorado.
Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado.
Am J Prev Med. 2019 Oct;57(4):e125-e133. doi: 10.1016/j.amepre.2019.05.018. Epub 2019 Aug 27.
Tetanus, diphtheria, and acellular pertussis (Tdap) and influenza vaccines are recommended for pregnant women in each pregnancy, yet uptake is suboptimal. This study tested the efficacy of an online vaccine resource in increasing uptake of Tdap and influenza vaccines among pregnant women.
RCT.
SETTING/PARTICIPANTS: This study was conducted among women in the third trimester of pregnancy in an integrated healthcare system in Colorado in September 2013-July 2016, with data analysis in 2017-2018.
Women were randomly assigned to 1 of 3 arms: website with vaccine information and interactive social media components, website with vaccine information only, or usual care. Participants in the website with vaccine information and interactive social media components and website with vaccine information only arms had access to the same base vaccine content. The website with vaccine information and interactive social media components also included a blog, discussion forum, and "Ask a Question" portal.
Tdap and influenza vaccination. These outcomes were analyzed separately.
For influenza (n=289), women in both the website with vaccine information and interactive social media components (OR=2.19, 95% CI=1.06, 4.53) and website with vaccine information only (OR=2.20, 95% CI=1.03, 4.69) arms had higher vaccine uptake than the usual care arm. The proportions of women receiving the influenza vaccine were 57%, 55%, and 36% in the website with vaccine information and interactive social media components, website with vaccine information only, and usual care arms, respectively. For Tdap (n=173), there were no significant differences in vaccine uptake between study arms. The proportions of women receiving Tdap were 71%, 69%, and 68% in the website with vaccine information and interactive social media components, website with vaccine information only, and usual care arms, respectively.
Web-based vaccination information sent to pregnant women can positively influence maternal influenza vaccine uptake. Because of potential scalability, the impact of robust vaccination information websites should be studied in other settings.
This study is registered at www.clinicaltrials.gov NCT01873040.
破伤风、白喉和无细胞百日咳（Tdap）以及流感疫苗均被推荐给每位孕妇在孕期接种，但接种率并不理想。本研究旨在检验在线疫苗资源在提高孕妇 Tdap 和流感疫苗接种率方面的效果。
随机对照试验。
设置/参与者：这项研究于 2013 年 9 月至 2016 年 7 月在科罗拉多州的一个综合性医疗系统中处于妊娠晚期的女性中进行，2017 年至 2018 年进行数据分析。
将女性随机分配到 3 个组中的 1 个：包含疫苗信息和互动社交媒体组件的网站、仅包含疫苗信息的网站或常规护理。接种包含疫苗信息和互动社交媒体组件的网站和仅包含疫苗信息的网站的参与者可获得相同的基础疫苗内容。包含疫苗信息和互动社交媒体组件的网站还包括一个博客、讨论论坛和“提问”门户。
Tdap 和流感疫苗接种。这两种结局分别进行分析。
在流感（n=289）方面，接种包含疫苗信息和互动社交媒体组件（OR=2.19，95%CI=1.06，4.53）和仅包含疫苗信息的网站（OR=2.20，95%CI=1.03，4.69）的女性比常规护理组的疫苗接种率更高。接种流感疫苗的女性比例分别为接种包含疫苗信息和互动社交媒体组件的网站、仅包含疫苗信息的网站和常规护理组的 57%、55%和 36%。在 Tdap（n=173）方面，研究组之间的疫苗接种率没有显著差异。接种 Tdap 的女性比例分别为接种包含疫苗信息和互动社交媒体组件的网站、仅包含疫苗信息的网站和常规护理组的 71%、69%和 68%。
发送给孕妇的基于网络的疫苗信息可以积极影响母亲的流感疫苗接种率。由于潜在的可扩展性，应在其他环境中研究强大的疫苗信息网站的影响。
本研究在 www.clinicaltrials.gov 上注册，编号为 NCT01873040。
