Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado; Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.
Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado.
Am J Prev Med. 2018 Jul;55(1):44-54. doi: 10.1016/j.amepre.2018.04.010. Epub 2018 May 14.
Successful strategies are needed to address parental vaccine hesitancy, a significant public health issue. The study objective was to assess whether an Internet-based platform with vaccine information and interactive social media components improved parents' vaccine-related attitudes.
A three-arm RCT.
SETTING/PARTICIPANTS: The study was conducted in a large Colorado integrated healthcare organization. Parents were enrolled during September 2013 through October 2015 and followed through November 2016; data were analyzed in 2017. Parents, recruited during pregnancy, were given a survey about vaccine-related attitudes at enrollment (i.e., baseline) and when their child was aged 3-5 months and 12-15 months (Timepoints 1 and 2, respectively). Parental vaccine hesitancy was assessed at baseline.
Study participants were randomized to the following: a study website with vaccine information and social media components (VSM arm); a website with vaccine information only (VI); or usual care.
Change in parental vaccine attitudes over time by baseline degree of vaccine hesitancy.
Among 1,093 study participants, 945 (86.5%) completed all three surveys. Comparing baseline with Timepoint 1 among vaccine-hesitant parents, the VSM and VI arms were associated with significant improvements in attitudes regarding vaccination benefits compared to usual care (VSM mean change 0.23 on a 5-point scale, 95% CI=0.05, 0.40, VI mean change 0.22, 95% CI=0.04, 0.40). Comparing baseline with Timepoint 2 among hesitant parents, the VSM and VI arms were also associated with significant reductions in parental concerns about vaccination risks compared to usual care (VSM mean change -0.37, 95% CI= -0.60, -0.14, VI mean change -0.31, 95% CI= -0.55, -0.07). Self-efficacy around vaccine decision making also improved among vaccine-hesitant parents. No intervention effect was observed among parents not vaccine-hesitant at baseline.
Among vaccine-hesitant parents, an Internet-based intervention improved parents' attitudes about vaccines.
This study was registered at www.clinicaltrials.gov NCT01873040.
需要采取成功的策略来解决父母对疫苗的犹豫态度，这是一个重大的公共卫生问题。本研究的目的是评估一个包含疫苗信息和互动社交媒体组件的互联网平台是否能改善父母对疫苗相关的态度。
三臂 RCT。
研究地点/参与者：该研究在科罗拉多州的一个大型综合医疗保健组织中进行。父母在 2013 年 9 月至 2015 年 10 月期间入组，并随访至 2016 年 11 月；数据分析于 2017 年进行。在怀孕期间招募的父母在入组时（即基线）和他们的孩子 3-5 个月和 12-15 个月时（分别为时间点 1 和 2）接受了一项关于疫苗相关态度的调查。在基线时评估父母的疫苗犹豫程度。
研究参与者被随机分配到以下三组：一个包含疫苗信息和社交媒体组件的研究网站（VSM 组）；一个只有疫苗信息的网站（VI 组）；或常规护理。
根据基线时的疫苗犹豫程度，比较父母疫苗态度随时间的变化。
在 1093 名研究参与者中，有 945 名（86.5%）完成了所有三次调查。在疫苗犹豫的父母中，与基线相比，VSM 和 VI 组在接种疫苗的益处方面的态度有显著改善，与常规护理相比（VSM 平均变化 0.23，95%置信区间为 0.05，0.40，VI 平均变化 0.22，95%置信区间为 0.04，0.40）。在犹豫的父母中，与基线相比，在时间点 2 时，VSM 和 VI 组也与常规护理相比，父母对疫苗风险的担忧显著减少（VSM 平均变化 -0.37，95%置信区间为-0.60，-0.14，VI 平均变化 -0.31，95%置信区间为-0.55，-0.07）。在疫苗犹豫的父母中，关于疫苗决策的自我效能也有所提高。在基线时不犹豫的父母中，没有观察到干预效果。
在疫苗犹豫的父母中，基于互联网的干预措施改善了父母对疫苗的态度。
本研究在 www.clinicaltrials.gov 注册，NCT01873040。
