Department of Psychiatry, University of Oxford, Oxford, United Kingdom.
National Institute for Health Research Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom; UCL Institute of Ophthalmology, London, United Kingdom.
Ophthalmology. 2019 Nov;126(11):1500-1510. doi: 10.1016/j.ophtha.2019.06.029. Epub 2019 Jul 5.
To describe the distribution of corneal hysteresis (CH) in a large cohort and explore its associated factors and possible clinical applications.
Cross-sectional study within the UK Biobank, a large cohort study in the United Kingdom.
We analyzed CH data from 93 345 eligible participants in the UK Biobank cohort, aged 40 to 69 years.
All analyses were performed using left eye data. Linear regression models were used to evaluate associations between CH and demographic, lifestyle, ocular, and systemic variables. Piecewise logistic regression models were used to explore the relationship between self-reported glaucoma and CH.
Corneal hysteresis (mmHg).
The mean CH was 10.6 mmHg (10.4 mmHg in male and 10.8 mmHg in female participants). After adjusting for covariables, CH was significantly negatively associated with male sex, age, black ethnicity, self-reported glaucoma, diastolic blood pressure, and height. Corneal hysteresis was significantly positively associated with smoking, hyperopia, diabetes, systemic lupus erythematosus (SLE), greater deprivation (Townsend index), and Goldmann-correlated intraocular pressure (IOPg). Self-reported glaucoma and CH were significantly associated when CH was less than 10.1 mmHg (odds ratio, 0.86; 95% confidence interval, 0.79-0.94 per mmHg CH increase) after adjusting for covariables. When CH exceeded 10.1 mmHg, there was no significant association between CH and self-reported glaucoma.
In our analyses, CH was significantly associated with factors including age, sex, and ethnicity, which should be taken into account when interpreting CH values. In our cohort, lower CH was significantly associated with a higher prevalence of self-reported glaucoma when CH was less than 10.1 mmHg. Corneal hysteresis may serve as a biomarker aiding glaucoma case detection.
描述大样本人群中角膜滞后（CH）的分布情况，并探讨其相关因素及可能的临床应用。
英国生物库（United Kingdom Biobank，UKB）内的横断面研究，UKB 是英国的一项大型队列研究。
我们分析了 UKB 队列中 93345 名符合条件的参与者的 CH 数据，年龄在 40 至 69 岁之间。
所有分析均使用左眼数据进行。线性回归模型用于评估 CH 与人口统计学、生活方式、眼部和全身变量之间的关系。分段逻辑回归模型用于探讨自我报告的青光眼与 CH 之间的关系。
角膜滞后（mmHg）。
平均 CH 为 10.6mmHg（男性参与者为 10.4mmHg，女性参与者为 10.8mmHg）。在校正协变量后，CH 与男性性别、年龄、黑人种族、自我报告的青光眼、舒张压和身高呈显著负相关。CH 与吸烟、远视、糖尿病、系统性红斑狼疮（systemic lupus erythematosus，SLE）、较高的贫困程度（Townsend 指数）和 Goldmann 相关眼压（Goldmann-correlated intraocular pressure，IOPg）呈显著正相关。在校正协变量后，当 CH 小于 10.1mmHg 时，自我报告的青光眼和 CH 之间存在显著相关性（优势比，每增加 1mmHg CH 下降 0.86；95%置信区间，0.79-0.94）。当 CH 超过 10.1mmHg 时，CH 与自我报告的青光眼之间没有显著关联。
在我们的分析中，CH 与年龄、性别和种族等因素显著相关，在解释 CH 值时应考虑这些因素。在我们的队列中，当 CH 小于 10.1mmHg 时，较低的 CH 与自我报告的青光眼患病率显著升高相关。CH 可能成为辅助青光眼病例检测的生物标志物。
