Bartzoulianou Rodanthi C, Coleman Anne L, Wilson M Roy, Harris Alon, Bougioukas Konstantinos I, Pappas Theofanis, Giannoulis Dimitrios A, Yu Fei, Raptou Anastasia, Tzoanou Grigoria, Topouzis Fotis
1st Department of Ophthalmology, Aristotle University of Thessaloniki, AHEPA Hospital.
UCLA Stein Eye Institute, David Geffen School of Medicine at UCLA, University of California Los Angeles, CA.
J Glaucoma. 2025 Apr 1;34(4):275-281. doi: 10.1097/IJG.0000000000002541. Epub 2025 Jan 23.
Corneal hysteresis (CH) was positively associated with female sex and central corneal thickness, and negatively with age and axial length. Diabetes showed no significant association with CH in the adjusted models.
To provide values of corneal hysteresis (CH) in an elderly, healthy Greek population and to investigate its association with demographic, ocular, and systemic factors.
Cross-sectional population-based study. Out of 1092 participants in the incidence cohort of the Thessaloniki Eye Study (TES) who were re-examined between 2013 and 2015, there were 801 eligible subjects in this study according to prespecified criteria. All subjects underwent an interview and a comprehensive clinical examination. Demographic data and medical and ophthalmic, family, and smoking histories were recorded. CH was evaluated with an Ocular Response Analyzer (ORA).
The mean age of study subjects was 79.7±3.9 years and 345 out of 801 participants (43.1%) were female. The mean CH among all subjects was 10.1±1.5 mm Hg. After adjusting for age, sex, central corneal thickness (CCT), axial length (AL), and diabetes, CH was positively associated with female sex (β=0.446; P <0.0001) and CCT (β=0.017; P <0.0001), and negatively associated with age (β=-0.024; P =0.038) and AL (β=-0.181; P <0.0001). There was no association between CH and diabetes (β=0.186; P =0.10). In a supplementary multivariable analysis of a smaller sample size, where we included corneal curvature (CC) as an additional covariate, no association was found between CH and CC (β=-0.235; P =0.26) or age (β=-0.023; P =0.09).
This study outlined variations in CH among a Greek population. CH decreased with advancing age while women had greater CH compared with men. In addition, eyes with thinner corneas and longer AL had lower CH values. No significant associations were found between CH and CC or the presence of diabetes.
角膜滞后（CH）与女性性别和中央角膜厚度呈正相关，与年龄和眼轴长度呈负相关。在调整后的模型中，糖尿病与CH无显著关联。
提供希腊老年健康人群的角膜滞后（CH）值，并研究其与人口统计学、眼部和全身因素的关联。
基于人群的横断面研究。在塞萨洛尼基眼病研究（TES）发病队列的1092名参与者中，2013年至2015年期间接受复查的有801名符合预先设定标准的合格受试者。所有受试者均接受了访谈和全面的临床检查。记录了人口统计学数据以及医疗、眼科、家族和吸烟史。使用眼反应分析仪（ORA）评估CH。
研究对象的平均年龄为79.7±3.9岁，801名参与者中有345名（43.1%）为女性。所有受试者的平均CH为10.1±1.5 mmHg。在调整年龄、性别、中央角膜厚度（CCT）、眼轴长度（AL）和糖尿病后，CH与女性性别（β=0.446；P<0.0001）和CCT（β=0.017；P<0.0001）呈正相关，与年龄（β=-0.024；P=0.038）和AL（β=-0.181；P<0.0001）呈负相关。CH与糖尿病之间无关联（β=0.186；P=0.10）。在一个样本量较小的补充多变量分析中，我们将角膜曲率（CC）作为一个额外的协变量纳入，未发现CH与CC（β=-0.235；P=0.26）或年龄（β=-0.023；P=0.09）之间存在关联。
本研究概述了希腊人群中CH的变化情况。CH随年龄增长而降低，女性的CH高于男性。此外，角膜较薄和AL较长的眼睛CH值较低。未发现CH与CC或糖尿病的存在之间存在显著关联。
