The London Breast Institute, Princess Grace Hospital, London, U.K.
Department of General Surgery, Khyber Teaching Hospital, Peshawar, Pakistan.
In Vivo. 2019 Sep-Oct;33(5):1421-1423. doi: 10.21873/invivo.11619.
BACKGROUND/AIM: Bisphenol A (BPA) is a ubiquitous substance found in a wide array of consumer products and healthcare consumables, and at low doses in drinking water. Currently, in the UK, it is classed as a low-risk substance with little potential for harm. It has been known to have effects on oestrogen receptors. The implications of this for public safety is currently subject to debate.
In this study, we review recent literature regarding the effects and safety of BPA, and discuss the potential implications, in particular from the perspective of human breast oncogenesis.
Recent evidence suggests that low-doses of endocrine disruptors, such as BPA, could have profound effects in breast development and cancer risk. Recent studies in murine models suggest that BPA could contribute to breast oncogenesis via several pathways. The position of regulators should shift accordingly to safeguard the public interest.
背景/目的：双酚 A（BPA）是一种广泛存在于各种消费产品和医疗保健用品中的物质，并且在饮用水中也以低剂量存在。目前，在英国，它被归类为低风险物质，几乎没有潜在的危害。它已被证明对雌激素受体有影响。这对公众安全的影响目前仍存在争议。
在这项研究中，我们回顾了最近关于 BPA 的作用和安全性的文献，并讨论了其潜在的影响，特别是从人类乳腺癌发生的角度来看。
最近的证据表明，低剂量的内分泌干扰物，如 BPA，可能对乳房发育和癌症风险产生深远影响。最近在小鼠模型中的研究表明，BPA 可能通过多种途径促进乳腺癌发生。监管者的立场应相应转变，以维护公众利益。
