骨保护素和中性粒细胞明胶酶相关脂质运载蛋白对多发伤多器官衰竭的预测价值。
Predictive Value of Osteoprotegerin and Neutrophil Gelatinase-associated Lipocalin on Multiple Organ Failure in Multiple Trauma.
机构信息
Trauma Department, Hannover Medical School, Hannover, Germany.
Department of General, Trauma and Reconstructive Surgery, Ludwig-Maximilians-Universität München, Munich, Germany.
出版信息
In Vivo. 2019 Sep-Oct;33(5):1573-1580. doi: 10.21873/invivo.11639.
BACKGROUND/AIM: Multiple organ dysfunction syndrome (MODS) is the leading cause of late posttraumatic mortality. This study analyzed the prognostic values of osteoprotegerin (OPG) and neutrophil gelatinase-associated lipocalin (NGAL/lipocalin 2) compared to interleukin-6 (IL-6) in multiply injured patients.
PATIENTS AND METHODS
A retrospective observational cohort study on multiply injured patients with an injury severity score (ISS) of ≥16 was performed. OPG, NGAL and IL-6 blood concentrations were measured. Statistical analysis comprised receiver-operating-characteristic (ROC) analysis with the corresponding area under the curve (AUC).
RESULTS
Thirty-nine patients with a mean ISS of 34±11 were included. Fourteen patients (36%) developed MODS and 8 patients (21%) died. Plasma levels of NGAL, OPG, and IL-6 were significantly elevated in the MODS+ group. Each biomarker positively correlated with MODS score and diagnosis of MODS.
CONCLUSION
NGAL and OPG might be indicative of MODS and could have the potential to be biomarkers in the early detection of patients at risk of posttraumatic MODS.
背景/目的：多器官功能障碍综合征（MODS）是创伤后晚期死亡的主要原因。本研究分析了与白细胞介素 6（IL-6）相比，骨保护素（OPG）和中性粒细胞明胶酶相关脂质运载蛋白（NGAL/脂质运载蛋白 2）在多发伤患者中的预后价值。
患者和方法
对损伤严重程度评分（ISS）≥16 的多发伤患者进行回顾性观察队列研究。测定 OPG、NGAL 和 IL-6 血浓度。统计分析包括接收者操作特征（ROC）分析及相应的曲线下面积（AUC）。
结果
共纳入 39 例平均 ISS 为 34±11 的患者。14 例（36%）发生 MODS，8 例（21%）死亡。MODS+组的 NGAL、OPG 和 IL-6 血浆水平明显升高。每种生物标志物与 MODS 评分和 MODS 诊断呈正相关。
结论
NGAL 和 OPG 可能提示 MODS，并有可能成为创伤后发生 MODS 高危患者早期检测的生物标志物。
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