• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Predictive Value of Osteoprotegerin and Neutrophil Gelatinase-associated Lipocalin on Multiple Organ Failure in Multiple Trauma.骨保护素和中性粒细胞明胶酶相关脂质运载蛋白对多发伤多器官衰竭的预测价值。
In Vivo. 2019 Sep-Oct;33(5):1573-1580. doi: 10.21873/invivo.11639.
2
Increased Neutrophil Gelatinase-Associated Lipocalin is Associated with Mortality and Multiple Organ Dysfunction Syndrome in Severe Sepsis and Septic Shock.中性粒细胞明胶酶相关脂质运载蛋白升高与严重脓毒症和脓毒性休克的死亡率及多器官功能障碍综合征相关。
Shock. 2015 Sep;44(3):234-8. doi: 10.1097/SHK.0000000000000408.
3
Which score should be used for posttraumatic multiple organ failure? - Comparison of the MODS, Denver- and SOFA- Scores.创伤后多器官功能衰竭应使用哪个评分？——多器官功能障碍评分（MODS）、丹佛评分和序贯器官衰竭评估（SOFA）评分的比较
Scand J Trauma Resusc Emerg Med. 2016 Nov 3;24(1):130. doi: 10.1186/s13049-016-0321-5.
4
[Predictive value of combining of anatomy scoring system and physiological scoring system for the diagnosis of multiple organ dysfunction syndrome in patients with severe trauma].[解剖学评分系统与生理学评分系统联合应用对严重创伤患者多器官功能障碍综合征的诊断预测价值]
Zhonghua Shao Shang Za Zhi. 2016 Feb;32(2):105-8. doi: 10.3760/cma.j.issn.1009-2587.2016.02.009.
5
The potential of adipokines in identifying multiple trauma patients at risk of developing multiple organ dysfunction syndrome.脂肪细胞因子在识别多种创伤患者发生多器官功能障碍综合征风险中的作用。
Eur J Med Res. 2021 Apr 30;26(1):38. doi: 10.1186/s40001-021-00511-z.
6
Neutrophil gelatinase-associated lipocalin as a biomarker for short-term outcomes among trauma patients: A single-center observational study.中性粒细胞明胶酶相关脂质运载蛋白作为创伤患者短期预后的生物标志物：一项单中心观察性研究。
PLoS One. 2021 May 10;16(5):e0251319. doi: 10.1371/journal.pone.0251319. eCollection 2021.
7
[Establishment of multiple organ dysfunction syndrome early warning score in patients with severe trauma and its clinical significance: a multicenter study].[严重创伤患者多器官功能障碍综合征预警评分的建立及其临床意义：一项多中心研究]
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2018 Jan;30(1):41-46. doi: 10.3760/cma.j.issn.2095-4352.2018.01.008.
8
Serum Neutrophil Gelatinase-Associated Lipocalin: A Diagnostic Marker in Pediatric Sepsis.血清中性粒细胞明胶酶相关脂质运载蛋白：小儿脓毒症的一种诊断标志物
Pediatr Crit Care Med. 2017 Jun;18(6):e245-e252. doi: 10.1097/PCC.0000000000001186.
9
Early Immunologic Response in Multiply Injured Patients With Orthopaedic Injuries Is Associated With Organ Dysfunction.多发伤合并骨科损伤患者的早期免疫反应与器官功能障碍有关。
J Orthop Trauma. 2019 May;33(5):220-228. doi: 10.1097/BOT.0000000000001437.
10
IMPACT probability of poor outcome and plasma cytokine concentrations are associated with multiple organ dysfunction syndrome following traumatic brain injury.创伤性脑损伤后，预后不良的可能性和血浆细胞因子浓度与多器官功能障碍综合征有关。
J Neurosurg. 2019 Jan 11;131(6):1931-1937. doi: 10.3171/2018.8.JNS18676. Print 2019 Dec 1.

引用本文的文献

1
Dysregulation of iron transport-related biomarkers in blood leukocytes is associated with poor prognosis of early trauma.血液白细胞中铁转运相关生物标志物的失调与早期创伤的不良预后相关。
Heliyon. 2024 Feb 28;10(5):e27000. doi: 10.1016/j.heliyon.2024.e27000. eCollection 2024 Mar 15.
2
Identification of biomarkers and the mechanisms of multiple trauma complicated with sepsis using metabolomics.采用代谢组学技术鉴定多发创伤合并脓毒症的生物标志物及作用机制。
Front Public Health. 2022 Aug 4;10:923170. doi: 10.3389/fpubh.2022.923170. eCollection 2022.
3
Neutrophil Gelatinase-associated Lipocalin Predicts Post-traumatic Acute Kidney Injury in Severely Injured Patients.中性粒细胞明胶酶相关载脂蛋白预测严重创伤患者创伤后急性肾损伤。
In Vivo. 2021 Sep-Oct;35(5):2755-2762. doi: 10.21873/invivo.12560.
4
Neutrophil gelatinase-associated lipocalin as a biomarker for short-term outcomes among trauma patients: A single-center observational study.中性粒细胞明胶酶相关脂质运载蛋白作为创伤患者短期预后的生物标志物：一项单中心观察性研究。
PLoS One. 2021 May 10;16(5):e0251319. doi: 10.1371/journal.pone.0251319. eCollection 2021.
5
Biomarkers of Kidney Injury in Very-low-birth-weight Preterm Infants: Influence of Maternal and Neonatal Factors.极低出生体重早产儿肾脏损伤的生物标志物：母体和新生儿因素的影响。
In Vivo. 2020 May-Jun;34(3):1333-1339. doi: 10.21873/invivo.11910.

本文引用的文献

1
STARD 2015: an updated list of essential items for reporting diagnostic accuracy studies.STARD 2015：报告诊断准确性研究的必备项目更新清单。
BMJ. 2015 Oct 28;351:h5527. doi: 10.1136/bmj.h5527.
2
The potential utility of urinary biomarkers for risk prediction in combat casualties: a prospective observational cohort study.尿生物标志物在战斗伤员风险预测中的潜在效用：一项前瞻性观察性队列研究。
Crit Care. 2015 Jun 16;19(1):252. doi: 10.1186/s13054-015-0965-y.
3
Whole blood neutrophil gelatinase-associated lipocalin predicts acute kidney injury in burn patients.全血中性粒细胞明胶酶相关脂质运载蛋白可预测烧伤患者的急性肾损伤。
J Surg Res. 2015 Jun 15;196(2):382-7. doi: 10.1016/j.jss.2015.03.033. Epub 2015 Mar 20.
4
Neutrophil gelatinase-associated lipocalin: ready for routine clinical use? An international perspective.中性粒细胞明胶酶相关脂质运载蛋白：准备好用于常规临床了吗？国际视角。
Blood Purif. 2014;37(4):271-85. doi: 10.1159/000360689. Epub 2014 Jul 3.
5
Epidemiology and risk factors of multiple-organ failure after multiple trauma: an analysis of 31,154 patients from the TraumaRegister DGU.多发伤后多器官衰竭的流行病学和危险因素：来自创伤登记处 DGU 的 31154 例患者的分析。
J Trauma Acute Care Surg. 2014 Apr;76(4):921-7; discussion 927-8. doi: 10.1097/TA.0000000000000199.
6
Temporal trends of postinjury multiple-organ failure: still resource intensive, morbid, and lethal.创伤后多器官衰竭的时间趋势：仍然需要大量资源，且病情严重，死亡率高。
J Trauma Acute Care Surg. 2014 Mar;76(3):582-92, discussion 592-3. doi: 10.1097/TA.0000000000000147.
7
Neutrophil gelatinase-associated lipocalin as a biomarker of acute kidney injury: a critical evaluation of current status.中性粒细胞明胶酶相关脂质运载蛋白作为急性肾损伤的生物标志物：对当前状况的批判性评估
Ann Clin Biochem. 2014 May;51(Pt 3):335-51. doi: 10.1177/0004563214521795. Epub 2014 Feb 11.
8
Cytokine levels (IL-4, IL-6, IL-8 and TGFβ) as potential biomarkers of systemic inflammatory response in trauma patients.细胞因子水平（IL-4、IL-6、IL-8 和 TGFβ）作为创伤患者全身炎症反应的潜在生物标志物。
Int Orthop. 2014 Jun;38(6):1303-9. doi: 10.1007/s00264-013-2261-2. Epub 2014 Jan 9.
9
Neutrophil gelatinase associated lipocalin as an indicator of acute kidney injury and inflammation in burned children.中性粒细胞明胶酶相关脂质运载蛋白作为烧伤儿童急性肾损伤和炎症的指标
Burns. 2014 Jun;40(4):648-54. doi: 10.1016/j.burns.2013.09.004. Epub 2013 Sep 21.
10
The changing nature of death on the trauma service.创伤服务中死亡性质的变化。
J Trauma Acute Care Surg. 2013 Aug;75(2):195-201. doi: 10.1097/TA.0b013e3182997865.

骨保护素和中性粒细胞明胶酶相关脂质运载蛋白对多发伤多器官衰竭的预测价值。

Predictive Value of Osteoprotegerin and Neutrophil Gelatinase-associated Lipocalin on Multiple Organ Failure in Multiple Trauma.

机构信息

Trauma Department, Hannover Medical School, Hannover, Germany.

Department of General, Trauma and Reconstructive Surgery, Ludwig-Maximilians-Universität München, Munich, Germany.

出版信息

In Vivo. 2019 Sep-Oct;33(5):1573-1580. doi: 10.21873/invivo.11639.

DOI:10.21873/invivo.11639
PMID:31471407
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6754992/
Abstract

BACKGROUND/AIM: Multiple organ dysfunction syndrome (MODS) is the leading cause of late posttraumatic mortality. This study analyzed the prognostic values of osteoprotegerin (OPG) and neutrophil gelatinase-associated lipocalin (NGAL/lipocalin 2) compared to interleukin-6 (IL-6) in multiply injured patients.

PATIENTS AND METHODS

A retrospective observational cohort study on multiply injured patients with an injury severity score (ISS) of ≥16 was performed. OPG, NGAL and IL-6 blood concentrations were measured. Statistical analysis comprised receiver-operating-characteristic (ROC) analysis with the corresponding area under the curve (AUC).

RESULTS

Thirty-nine patients with a mean ISS of 34±11 were included. Fourteen patients (36%) developed MODS and 8 patients (21%) died. Plasma levels of NGAL, OPG, and IL-6 were significantly elevated in the MODS+ group. Each biomarker positively correlated with MODS score and diagnosis of MODS.

CONCLUSION

NGAL and OPG might be indicative of MODS and could have the potential to be biomarkers in the early detection of patients at risk of posttraumatic MODS.

摘要

背景/目的：多器官功能障碍综合征（MODS）是创伤后晚期死亡的主要原因。本研究分析了与白细胞介素 6（IL-6）相比，骨保护素（OPG）和中性粒细胞明胶酶相关脂质运载蛋白（NGAL/脂质运载蛋白 2）在多发伤患者中的预后价值。

患者和方法

对损伤严重程度评分（ISS）≥16 的多发伤患者进行回顾性观察队列研究。测定 OPG、NGAL 和 IL-6 血浓度。统计分析包括接收者操作特征（ROC）分析及相应的曲线下面积（AUC）。

结果

共纳入 39 例平均 ISS 为 34±11 的患者。14 例（36%）发生 MODS，8 例（21%）死亡。MODS+组的 NGAL、OPG 和 IL-6 血浆水平明显升高。每种生物标志物与 MODS 评分和 MODS 诊断呈正相关。

结论

NGAL 和 OPG 可能提示 MODS，并有可能成为创伤后发生 MODS 高危患者早期检测的生物标志物。