人类免疫缺陷病毒感染成人血清单克隆免疫球蛋白的同型性
Isotypy of serum monoclonal immunoglobulins in human immunodeficiency virus-infected adults.
作者信息
Briault S, Courtois-Capella M, Duarte F, Aucouturier P, Preud'Homme J L
机构信息
Laboratory of Immunology and Immunopathology (CNRS UA 1172), Poitiers University Hospital, France.
出版信息
Clin Exp Immunol. 1988 Nov;74(2):182-4.
Abstract
The classes, subclasses and light chain types of 78 serum monoclonal immunoglobulins (MoIg) from adult patients affected with various clinical forms of human immunodeficiency virus (HIV) infection were studied by a sensitive Western blot technique. The incidence of MoIg-containing sera was 26% in a systematic study. Most of these sera contained several (up to eight) detectable MoIg. These MoIg were IgG (91%) and IgM (9%) with a predominance of light chains of the lambda type (kappa:lambda ratio 0.6). The subclass distribution of monoclonal IgG was strikingly different from that observed in myeloma; much less IgG1 and much more IgG3 and IgG4.
摘要
采用灵敏的蛋白质印迹技术，对78例患有各种临床类型人类免疫缺陷病毒（HIV）感染的成年患者血清中的单克隆免疫球蛋白（MoIg）的类别、亚类和轻链类型进行了研究。在一项系统性研究中，含MoIg血清的发生率为26%。这些血清中的大多数含有几种（多达8种）可检测到的MoIg。这些MoIg为IgG（91%）和IgM（9%），以λ型轻链为主（κ:λ比例为0.6）。单克隆IgG的亚类分布与骨髓瘤中观察到的情况显著不同；IgG1较少，而IgG3和IgG4较多。
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