一名骨髓瘤患者体内存在三种单克隆IgG成分，一种IgG4（λ）、一种IgG2（κ）以及一种IgG1/IgG3（κ）Gm（f，b）杂交成分。
Three monoclonal IgG components, an IgG4(lambda), an IgG2(kappa) and an IgG1/IgG3 (kappa) Gm(f,b) hybrid, in a single myeloma patient.
作者信息
Milosevic-Jovcic N, Dovezenski N, Jovanovic L, Rolovic Z, Gotic M, Radosevic N, Suvajdzic N, Tosic L
机构信息
Institute for Medical Research, School of Medicine, University of Belgrade, Serbia, Yugoslavia.
出版信息
Eur J Haematol. 1995 May;54(5):288-95.
An unusual triclonal IgG combination in the serum of a 56-year old male with clinical stage IIIB multiple myeloma is reported. The patient initially had an IgG4(lambda) monoclonal protein in his serum and later developed an IgG2(kappa) and an IgG (kappa) which possessed the characteristics of both IgG1 and IgG3 subclasses with an unusual combination of allotypic markers. Three M-proteins did not share idiotypic determinants. A rare class-switch recombination followed by mutation has been considered as a possible mechanism leading to this combination.
报道了一名56岁临床III B期多发性骨髓瘤男性患者血清中一种不寻常的三克隆IgG组合。该患者最初血清中有IgG4（λ）单克隆蛋白，后来又出现了IgG2（κ）和一种IgG（κ），后者具有IgG1和IgG3亚类的特征以及异型标记的不寻常组合。三种M蛋白不共享独特型决定簇。一种罕见的类别转换重组后发生突变被认为是导致这种组合的一种可能机制。
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