Hoehne Sabrina N, Kohen Casey J, Puschner Birgit, Gennity Ingrid, Hagley Simon P, Farrell Kate S, Unger Karin, Cagle Laura A, Jandrey Karl E
William R. Pritchard Veterinary Medical Teaching Hospital, University of California, Davis, CA.
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA.
J Vet Emerg Crit Care (San Antonio). 2019 Nov;29(6):690-695. doi: 10.1111/vec.12888. Epub 2019 Aug 31.
To describe the clinical signs, clinicopathologic abnormalities, treatment, and outcome after IV administration of polyethylene glycol 3350 (PEG3350) in a cat.
A cat was inadvertently administered 6 g/kg of PEG3350 in electrolyte solution, IV, resulting in severe hypernatremia (203 mmol/L), diffuse encephalopathy, hemolysis, and moderate azotemia. The hemolysis and acute kidney injury observed immediately following PEG3350 administration resolved with supportive care. Administration of IV and oral electrolyte-free water slowly corrected the hypernatremia and the neurologic signs subsequently improved. Complete resolution of clinical signs was documented one month following hospital discharge. The PEG3350 concentrations in serum, plasma, and urine samples confirmed toxic exposure to PEG3350. Efficacy of treatment was evident by decreasing concentrations of PEG3350 in serum after the first 24 hours of treatment. Renal elimination of PEG3350 was significant and PEG3350 was still detected in the urine 17 days after exposure.
This is the first report to describe the clinical signs and clinicopathologic abnormalities in a cat intoxicated with IV PEG3350. Potential pathophysiologic mechanisms are discussed, and the successful supportive medical treatment is outlined.
描述猫静脉注射聚乙二醇3350（PEG3350）后的临床体征、临床病理异常、治疗及预后情况。
一只猫意外静脉注射了6 g/kg溶解于电解质溶液中的PEG3350，导致严重高钠血症（203 mmol/L）、弥漫性脑病、溶血和中度氮质血症。PEG3350注射后立即出现的溶血和急性肾损伤经支持治疗后得到缓解。静脉输注和口服无电解质水缓慢纠正了高钠血症，随后神经体征有所改善。出院后1个月记录到临床体征完全消退。血清、血浆和尿液样本中的PEG3350浓度证实存在PEG3350中毒暴露。治疗24小时后血清中PEG3350浓度降低，表明治疗有效。PEG3350经肾脏大量排泄，暴露17天后尿液中仍可检测到PEG3350。
这是首篇描述静脉注射PEG3350中毒猫的临床体征和临床病理异常的报告。文中讨论了潜在的病理生理机制，并概述了成功的支持性药物治疗方法。
