Institute of Life Sciences, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Cluj-Napoca, Romania.
Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Cluj-Napoca, Romania.
J Sci Food Agric. 2020 Jan 30;100(2):483-499. doi: 10.1002/jsfa.10010. Epub 2019 Oct 13.
There is an urgent need to improve human diet globally. Compelling evidence gathered over the past several decades suggests that a suboptimal diet is associated with many chronic diseases and may be responsible for more deaths than any other risks worldwide. The main components in our diet that need higher intake are whole grains, fruit and vegetables, and nuts and seeds; all of these are important sources of dietary fiber and polyphenols. The health benefits of dietary fiber and polyphenols are also supported by several decades of valuable research. However, the conclusions drawn from interventional human trials are not straightforward and the action mechanisms in improving human health are not fully understood. Moreover, there is a great inter-individual variation caused by different individual capabilities of processing, absorbing and using these compounds effectively. Data on the bioavailability and bioefficacy of hydroxycinnamic acids (HCAs) are limited when compared to other classes of polyphenols (e.g. anthocyanins). This review aims to summarize the latest research advances related to HCA bioavailability and their biological effects revealed by epidemiological data, pre-clinical and clinical studies. Moreover, we aim to review the effects of HCAs on gut microbiota diversity and function and its respective influence on host health. © 2019 Society of Chemical Industry.
全球急需改善人类饮食。过去几十年收集的有力证据表明，饮食不均衡与许多慢性疾病有关，其导致的死亡人数可能超过世界其他任何风险因素。我们饮食中需要增加摄入的主要成分是全谷物、水果和蔬菜、坚果和种子；所有这些都是膳食纤维和多酚的重要来源。膳食纤维和多酚的健康益处也得到了几十年有价值的研究的支持。然而，干预性人体试验得出的结论并不简单，改善人类健康的作用机制也不完全清楚。此外，由于个体有效处理、吸收和利用这些化合物的能力不同，个体之间存在很大的差异。与其他类别的多酚（如花青素）相比，关于羟基肉桂酸（HCAs）的生物利用度和生物功效的数据有限。本文综述了流行病学数据、临床前和临床研究中与 HCA 生物利用度及其生物学效应相关的最新研究进展。此外，我们还旨在综述 HCAs 对肠道微生物多样性和功能的影响及其对宿主健康的各自影响。 © 2019 英国化学学会。
