de Abreu Murilo S, Genario Rafael, Giacomini Ana C V V, Demin Konstantin A, Lakstygal Anton M, Amstislavskaya Tamara G, Fontana Barbara Dotto, Parker Matthew O, Kalueff Allan V
Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA.
Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil.
Neuroscience. 2020 Oct 1;445:3-11. doi: 10.1016/j.neuroscience.2019.08.034. Epub 2019 Aug 29.
Neurodevelopmental disorders (NDDs) caused by aberrant brain growth and development are life-long, debilitating illnesses that markedly impair the quality of life. Animal models are a valuable tool for studying NDD pathobiology and therapies. Mounting evidence suggests the zebrafish (Danio rerio) as a useful model organism to study NDDs, possessing both high physiological homology to humans and sensitivity to pharmacological and genetic manipulations. Here, we summarize experimental models of NDDs in zebrafish and highlight the growing translational significance of zebrafish NDD-related phenotypes. We also emphasize the need in further development of zebrafish models of NDDs to improve our understanding of their pathogenesis and therapeutic treatments.
由大脑生长和发育异常引起的神经发育障碍（NDDs）是一种终身性、使人衰弱的疾病，会显著损害生活质量。动物模型是研究NDD病理生物学和治疗方法的宝贵工具。越来越多的证据表明，斑马鱼（Danio rerio）是研究NDDs的有用模式生物，它与人类具有高度的生理同源性，并且对药理和基因操作敏感。在这里，我们总结了斑马鱼中NDDs的实验模型，并强调了斑马鱼NDD相关表型日益增长的转化意义。我们还强调需要进一步开发斑马鱼NDD模型，以增进我们对其发病机制和治疗方法的理解。
