College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.
Genomics. 2020 Mar;112(2):1500-1515. doi: 10.1016/j.ygeno.2019.08.021. Epub 2019 Aug 28.
Prostate cancer is one of the leading causes of death in men worldwide, revealing a substantial heterogeneity in terms of molecular and clinical behaviors. Tumor infiltrating immune cell is associated with prognosis and response to immunotherapy in several cancer types. However, until now, the immune infiltrate profile of distinct subtypes for prostate cancer remains poorly characterized. In this study, using immune infiltration profiles as well as transcriptomic datasets, we characterized this subtype of prostate tumors. We observed that the FLI1 subtype of prostate tumors was highly enriched in immune system processes, immune related KEGG pathways and biological processes. We also expanded this approach to explore the immune infiltration profile of the high FLI1 expression subtype for skin cutaneous melanoma, similar results were found. Investigation of the association of immune infiltration features with the FLI1 expression demonstrated that many important features were associated with the FLI1 expression.
前列腺癌是全球男性死亡的主要原因之一，其在分子和临床行为方面表现出显著的异质性。肿瘤浸润免疫细胞与多种癌症的预后和免疫治疗反应相关。然而，到目前为止，不同亚型前列腺癌的免疫浸润特征仍描述不足。在这项研究中，我们使用免疫浸润特征和转录组数据集对这一前列腺肿瘤亚型进行了特征描述。我们观察到，前列腺肿瘤的 FLI1 亚型在免疫系统过程、免疫相关 KEGG 通路和生物学过程中高度富集。我们还扩展了这种方法来探索高 FLI1 表达亚型皮肤黑色素瘤的免疫浸润特征，发现了类似的结果。对免疫浸润特征与 FLI1 表达的关联进行研究表明，许多重要的特征与 FLI1 表达相关。
