College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Public Health College, Harbin Medical University, Harbin, China.
J Cell Mol Med. 2020 May;24(10):5501-5514. doi: 10.1111/jcmm.15205. Epub 2020 Apr 5.
Breast cancer is the most common cancer and the leading cause of cancer death among women in the world. Tumour-infiltrating lymphocytes were defined as the white blood cells left in the vasculature and localized in tumours. Recently, tumour-infiltrating lymphocytes were found to be associated with good prognosis and response to immunotherapy in tumours. In this study, to examine the influence of FLI1 in immune system in breast cancer, we interrogated the relationship between the FLI1 expression levels with infiltration levels of 28 immune cell types. By splitting the breast cancer samples into high and low expression FLI1 subtypes, we found that the high expression FLI1 subtype was enriched in many immune cell types, and the up-regulated differentially expressed genes between them were enriched in immune system processes, immune-related KEGG pathways and biological processes. In addition, many important immune-related features were found to be positively correlated with the FLI1 expression level. Furthermore, we found that the FLI1 was correlated with the immune-related genes. Our findings may provide useful help for recognizing the relationship between tumour immune microenvironment and FLI1, and may unravel clinical outcomes and immunotherapy utility for FLI1 in breast cancer.
乳腺癌是全世界女性最常见的癌症和癌症死亡的主要原因。肿瘤浸润淋巴细胞被定义为血管内残留的白细胞，并定位于肿瘤中。最近，肿瘤浸润淋巴细胞被发现与肿瘤的良好预后和免疫治疗反应有关。在这项研究中，为了研究 FLI1 在乳腺癌免疫系统中的影响，我们研究了 FLI1 表达水平与 28 种免疫细胞类型浸润水平之间的关系。通过将乳腺癌样本分为高表达和低表达 FLI1 亚型，我们发现高表达 FLI1 亚型富含许多免疫细胞类型，它们之间上调的差异表达基因富集在免疫系统过程、免疫相关 KEGG 途径和生物学过程中。此外，许多重要的免疫相关特征与 FLI1 的表达水平呈正相关。此外，我们发现 FLI1 与免疫相关基因相关。我们的研究结果可能为认识肿瘤免疫微环境与 FLI1 之间的关系提供有用的帮助，并可能为乳腺癌中 FLI1 的临床结局和免疫治疗应用提供新的思路。
