Zhang Congcong, Feng Xueling, Wang Bijia, Mao Zhiping, Xu Hong, Zhong Yi, Zhang Linping, Chen Xiaoyun, Sui Xiaofeng
Key Lab of Science and Technology of Eco-Textile, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Innovation Center for Textile Science and Technology of DHU, Donghua University, Shanghai, 201620, China.
Key Lab of Science and Technology of Eco-Textile, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Innovation Center for Textile Science and Technology of DHU, Donghua University, Shanghai, 201620, China.
Carbohydr Polym. 2019 Nov 15;224:115184. doi: 10.1016/j.carbpol.2019.115184. Epub 2019 Aug 8.
In this paper, we demonstrated an efficient continuous flow reactor packed with nanocellulose sponges made from the sustainable wood pulp. The key component of such reactor, a wood pulp derived nanocellulose sponge loaded with metal catalysts, exhibited high porosity and interconnected porous structure, providing low flow resistance and long-term stability to the flow reactors. The packing material showed good performance in Huisgen cycloaddition in both batch and continuous flow systems. Key comparisons between two systems including reaction kinetics, operating conditions and safety were particularly discussed. Various triazoles have been afforded with >99% conversion, even for gram scale reaction in flow systems. The continuous flow reactors we developed were easily derivatized, thus forming a general, economic and readily scalable platform as promising synthesis tools.
在本文中，我们展示了一种高效的连续流动反应器，该反应器填充有由可持续木浆制成的纳米纤维素海绵。这种反应器的关键组件，即负载金属催化剂的木浆衍生纳米纤维素海绵，具有高孔隙率和相互连接的多孔结构，为流动反应器提供了低流动阻力和长期稳定性。填充材料在间歇式和连续流动系统的Huisgen环加成反应中均表现出良好的性能。特别讨论了两个系统之间在反应动力学、操作条件和安全性方面的关键比较。即使在流动系统中进行克级反应，各种三唑的转化率也能达到>99%。我们开发的连续流动反应器易于衍生化，从而形成了一个通用、经济且易于扩展的平台，作为有前景的合成工具。
