Department of Medicine, Cardiology Division, U.S. Department of Veterans Affairs, VA Long Beach Healthcare System, 1 Hoag Drive, Newport Beach, CA 92663, USA.
Department of Medicine, Cardiology Division, Hoag Memorial Hospital, University of California, Irvine, Irvine, CA, USA.
Heart Fail Clin. 2019 Oct;15(4):497-507. doi: 10.1016/j.hfc.2019.06.002. Epub 2019 Aug 2.
Heart failure (HF) is a significant cause of cardiovascular morbidity and mortality for women in the United States. There are clear sex-specific differences between men and women in etiology, disease progression, and outcomes. HF with preserved ejection fraction is the most common type of HF in women, with hypertensive heart disease playing a pivotal role in its etiology. The Practice Guidelines do not endorse sex-specific recommendations for standard medical therapy of HF management. Women are underrepresented in HF clinical trials, leading to a lacking evidence base supporting sex-specific therapy. Further studies are needed to evaluate targeted HF therapies in women.
心力衰竭（HF）是美国女性心血管发病率和死亡率的重要原因。在病因、疾病进展和结局方面，男性和女性之间存在明显的性别特异性差异。射血分数保留的心力衰竭（HFpEF）是女性中最常见的心力衰竭类型，高血压性心脏病在其病因中起着关键作用。实践指南不支持针对 HF 管理的标准医学治疗的性别特异性建议。女性在 HF 临床试验中的代表性不足，导致缺乏支持性别特异性治疗的证据基础。需要进一步的研究来评估针对女性的 HF 靶向治疗。
