Walsh Mary Norine
The Care Group, LLC, 8333 Naab Road, Suite 400, Indianapolis, IN 46260, USA.
Curr Cardiol Rep. 2005 May;7(3):184-9. doi: 10.1007/s11886-005-0075-6.
Approximately half of the nearly 5 million people in the United States who have heart failure (HF) are women. The vast majority of women with advanced HF are elderly and many of them have HF with evidence of normal or preserved left ventricular systolic function. Although coronary disease is a common cause of HF for both men and women, a history of hypertension or diabetes places a woman at particular risk. Many fewer women than men have been enrolled in trials of therapies for patients with HF. Sex-specific results have been reported for some of these therapies, but not all trial data have been analyzed for sex-related differences. In spite of these differences in outcome, cardiac transplantation remains an important option for women with very advanced HF. Future research on therapies for HF will need to target women for enrollment, and all data analysis should include results that are stratified by sex.
在美国近500万心力衰竭（HF）患者中，约一半为女性。绝大多数晚期HF女性为老年人，其中许多人的HF伴有左心室收缩功能正常或保留的证据。尽管冠心病是男性和女性HF的常见病因，但高血压或糖尿病病史使女性面临特别风险。参与HF患者治疗试验的女性比男性少得多。已报告了其中一些疗法的性别特异性结果，但并非所有试验数据都针对性别相关差异进行了分析。尽管存在这些结果差异，但心脏移植仍然是晚期HF女性的重要选择。未来关于HF治疗的研究需要将女性纳入研究对象，并且所有数据分析都应包括按性别分层的结果。
