Pioneer Heart Institute, Cardiovascular Clinic of Nebraska, LLC, Lincoln, NE 68526, USA.
Heart and Vascular Institute, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University School of Medicine, 9500 Euclid Avenue, J3-4, Cleveland, OH 44195, USA.
Heart Fail Clin. 2019 Jan;15(1):19-27. doi: 10.1016/j.hfc.2018.08.003. Epub 2018 Oct 24.
There are millions of people affected by heart failure with reduced ejection fraction (HFrEF) as diagnosed with ejection fraction 40% or less by imaging. Established therapies have been proven through clinical trials on lifestyle interventions, medications, and devices for HFrEF to improve quality of life, heart function, and survival. Although there are more men than women suffering with HFrEF, there are no prospectively proven, sex-specific guideline therapies because women have been underrepresented in clinical trials. Current recommendations for medications in women with HFrEF are described in this article.
有数以百万计的人患有射血分数降低的心力衰竭（HFrEF），其通过影像学检查诊断为射血分数为 40%或更低。已通过临床试验证明，针对 HFrEF 的生活方式干预、药物和设备疗法可改善生活质量、心脏功能和生存率。尽管患有 HFrEF 的男性多于女性，但由于女性在临床试验中代表性不足，因此没有经过前瞻性证实的、性别特异性的指南治疗方法。本文描述了 HFrEF 女性患者的药物治疗建议。
