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Dorsal medullary serotonin and gastric motility: enhancement of effects by thyrotropin-releasing hormone.

作者信息

McCann M J, Hermann G E, Rogers R C

机构信息

Department of Physiology, Ohio State University College of Medicine, Columbus 43210.

出版信息

J Auton Nerv Syst. 1988 Nov;25(1):35-40. doi: 10.1016/0165-1838(88)90005-7.

DOI:10.1016/0165-1838(88)90005-7
PMID:3147290
Abstract

The effects of serotonin (5-HT) and thyrotropin-releasing hormone (TRH) on gastric motility patterns were investigated. Microinjection of serotonin (8 pmol in 4 nl) into the dorsal motor nucleus of the vagus produced a small increase in motility and tone, an effect which declined with repeated injections. As demonstrated previously, TRH (1 nmol in 1 microliter) applied to the surface of the dorsal medulla evoked a large increase in gastric motility and tone. After gastric motility returned to baseline following the TRH injection, we found that subsequent 5-HT injections, which previously evoked small changes in motility and tone, now evoked large increases in these indices. TRH augmentation of 5-HT-mediated effects on autonomic nuclei may be a significant feature in the alterations in gastric function that accompany the sleep-waking cycle and stress-related gastric pathology.

摘要

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