载脂蛋白 E 是评估非小细胞肺癌伴淋巴结转移患者的预测标志物。
Apolipoprotein E is a predictive marker for assessing non-small cell lung cancer patients with lymph node metastasis.
机构信息
Department of Pathology, Gyeongsang National University Changwon Hospital, Changwon, South Korea.
Department of Pathology, Gyeongsang National University Changwon Hospital, Changwon, South Korea; Gyeongsang National University School of Medicine, Jinju, South Korea; Gyeongsang Institute of Health Science, Jinju, South Korea.
出版信息
Pathol Res Pract. 2019 Oct;215(10):152607. doi: 10.1016/j.prp.2019.152607. Epub 2019 Aug 25.
BACKGROUND
Apolipoprotein E (APOE) modulates lipid homeostasis in the systemic circulation and induces inflammatory immune responses in the tumor microenvironment. We evaluated APOE expression in order to assess tumor progression in non-small cell lung cancer (NSCLC).
METHODS
Immunohistochemical staining for APOE was performed on tissue microarray blocks from 148 patients who had undergone surgery for NSCLC. The staining intensity and the proportion of APOE-positive tumor cells (based on distinct membranous and cytoplasmic staining) were scored. The relationships between APOE expression and clinical (age, sex, and smoking history) and pathological (TNM stage and histological type) factors were evaluated.
RESULTS
Positive APOE staining was observed in 93 (64.6%) patients. APOE expression patterns differed among NSCLC histological types (p-value = 0.016). Negative APOE expression was significantly associated with lymph node metastasis in NSCLC (p-value = 0.040). Both cases of N2 (stage IIIA) disease showed negative APOE expression.
CONCLUSIONS
APOE is a useful marker for assessing NSCLC patients with lymph node metastasis.
背景
载脂蛋白 E (APOE) 调节全身循环中的脂质稳态，并在肿瘤微环境中诱导炎症免疫反应。我们评估了 APOE 的表达，以评估非小细胞肺癌 (NSCLC) 的肿瘤进展。
方法
对 148 例接受 NSCLC 手术的患者的组织微阵列块进行 APOE 免疫组织化学染色。对染色强度和 APOE 阳性肿瘤细胞的比例（基于明显的膜和细胞质染色）进行评分。评估 APOE 表达与临床（年龄、性别和吸烟史）和病理（TNM 分期和组织学类型）因素之间的关系。
结果
93 例（64.6%）患者观察到 APOE 阳性染色。APOE 表达模式在 NSCLC 组织学类型之间存在差异（p 值=0.016）。APOE 阴性表达与 NSCLC 淋巴结转移显著相关（p 值=0.040）。2 例 N2（IIIa 期）疾病均表现为 APOE 阴性表达。
结论
APOE 是评估 NSCLC 淋巴结转移患者的有用标志物。
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