Institute of Biology, Leiden University, Leiden, The Netherlands.
Institute of Biology, Leiden University, Leiden, The Netherlands.
Trends Microbiol. 2020 Jan;28(1):68-80. doi: 10.1016/j.tim.2019.08.002. Epub 2019 Aug 29.
Chemotaxis is crucial for the survival of bacteria, and the signaling systems associated with it exhibit a high level of evolutionary conservation. The architecture of the chemosensory array and the signal transduction mechanisms have been extensively studied in Escherichia coli. More recent studies have revealed a vast diversity of the chemosensory system among bacteria. Unlike E. coli, some bacteria assemble more than one chemosensory array and respond to a broader spectrum of environmental and internal stimuli. These chemosensory arrays exhibit a great variability in terms of protein composition, cellular localization, and functional variability. Here, we present recent findings that emphasize the extent of diversity in chemosensory arrays and highlight the importance of studying chemosensory arrays in bacteria other than the common model organisms.
趋化作用对细菌的生存至关重要，与之相关的信号转导系统表现出高度的进化保守性。在大肠杆菌中，已经对化学感应阵列的结构和信号转导机制进行了广泛研究。最近的研究揭示了细菌中化学感应系统的巨大多样性。与大肠杆菌不同，一些细菌组装了不止一个化学感应阵列，并对更广泛的环境和内部刺激做出反应。这些化学感应阵列在蛋白质组成、细胞定位和功能多样性方面表现出很大的可变性。在这里，我们介绍了最近的发现，强调了化学感应阵列多样性的程度，并强调了在除常见模式生物以外的细菌中研究化学感应阵列的重要性。
