Mattiola Irene
Laboratory of Innate Immunity, Department of Microbiology, Infectious Diseases and Immunology, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany.
Berlin Institute of Health (BIH), Anna-Louisa-Karsch Strasse 2, 10117 Berlin, Germany.
Cancers (Basel). 2021 Jun 28;13(13):3225. doi: 10.3390/cancers13133225.
Natural killer (NK) cells are innate lymphoid cells playing an important role in anti-cancer immunity. NK cells are efficient in controlling the spreading of metastasis but are not very powerful in fighting against primary tumors. The NK cell capability to infiltrate and persist in the tumor microenvironment and to exert their antitumoral functions is often limited by tumor escape mechanisms. These tumor-mediated strategies not only induce NK cell tolerance but also interfere with the NK cell-dependent immune networking. This review will provide an overview of the tumor escape mechanisms impacting NK cells, identify the immune circuits regulating the NK cell-dependent antitumor immunity and revise the emerging therapeutic approaches to unleash NK cells in cancer.
自然杀伤（NK）细胞是先天性淋巴细胞，在抗癌免疫中发挥重要作用。NK细胞在控制转移扩散方面很有效，但在对抗原发性肿瘤方面不是很强大。NK细胞浸润并持续存在于肿瘤微环境中以及发挥其抗肿瘤功能的能力常常受到肿瘤逃逸机制的限制。这些肿瘤介导的策略不仅诱导NK细胞耐受，还干扰NK细胞依赖性免疫网络。本综述将概述影响NK细胞的肿瘤逃逸机制，确定调节NK细胞依赖性抗肿瘤免疫的免疫回路，并修订释放癌症中NK细胞的新兴治疗方法。
