QuantiFERON TB Gold Plus 用于结核病诊断：系统评价和荟萃分析。
QuantiFERON TB Gold Plus for the diagnosis of tuberculosis: a systematic review and meta-analysis.
机构信息
Clinical Epidemiology and Medical Statistics Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, Italy.
Clinical Epidemiology and Medical Statistics Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, Italy.
出版信息
J Infect. 2019 Nov;79(5):444-453. doi: 10.1016/j.jinf.2019.08.018. Epub 2019 Aug 29.
UNLABELLED
Estimated 2017 tuberculosis (TB) incidence is 10 million and mainly depends on the reservoir of individuals with latent TB infection (LTBI). Quantiferon-TB Gold in-Tube (QFT-GIT) is one of the tests used for LTBI detection. Since 2015 a new version, Quantiferon-TB Gold Plus (QFT-Plus) is available.
OBJECTIVES
To perform a systematic review and meta-analysis to assess the diagnostic accuracy for TB of QFT-Plus compared to QFT-GIT.
METHODS
PubMed and Scopus were used to detect records related to predefined strings from 2015 to 2018. Full text articles dealing with the sensitivity and/or specificity of the QFT-Plus vs. QFT-GIT for active-TB and LTBI detection were analyzed. Scientific quality and risk of bias were assessed using QADAS-2.
RESULTS
We selected 15 articles. Studies were mainly observational and cross-sectional, performed in 8 countries. Sample size differed in the TB group (27 to 164) compared to LTBI group (29 to 1031). Pooled sensitivity of QFT-Plus for active-TB was 0.94 (0.91 and 0.95 for TB1 and TB2, respectively), whereas pooled specificity for healthy status was 0.96. Pooled sensitivity and specificity for LTBI was 0.91 and 0.95, respectively.
CONCLUSIONS
We show that QFT-Plus is more sensitive compared to QFT-GIT for detecting M. tuberculosis infection, mainly due to TB2 responses.
未加标签
据估计，2017 年结核病（TB）发病率为 1000 万，主要取决于潜伏性结核感染（LTBI）个体的储存量。Quantiferon-TB Gold in-Tube（QFT-GIT）是用于 LTBI 检测的一种测试方法。自 2015 年以来，出现了一种新版本，即 Quantiferon-TB Gold Plus（QFT-Plus）。
目的
进行系统评价和荟萃分析，评估 QFT-Plus 检测结核的诊断准确性与 QFT-GIT 相比。
方法
使用 PubMed 和 Scopus 从 2015 年到 2018 年检索与预定义字符串相关的记录。分析了涉及 QFT-Plus 与 QFT-GIT 对活动性结核病和 LTBI 检测的敏感性和/或特异性的全文文章。使用 QADAS-2 评估科学质量和偏倚风险。
结果
我们选择了 15 篇文章。这些研究主要是观察性和横断面研究，在 8 个国家进行。TB 组的样本量（27 至 164）与 LTBI 组（29 至 1031）不同。QFT-Plus 对活动性 TB 的汇总敏感性为 0.94（TB1 和 TB2 分别为 0.91 和 0.95），而对健康状况的汇总特异性为 0.96。LTBI 的汇总敏感性和特异性分别为 0.91 和 0.95。
结论
我们表明，与 QFT-GIT 相比，QFT-Plus 检测结核感染的敏感性更高，主要是由于 TB2 反应。
Zotero 插件