块茎中具有生物活性的植物化学成分来自于 Rchb.f.
Bioactive phytochemicals from the tubers of Rchb.f.
机构信息
Department of Cosmeceutics, China Medical University, Taichung, Taiwan.
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung, Taiwan.
出版信息
Nat Prod Res. 2024 Nov;38(21):3848-3853. doi: 10.1080/14786419.2023.2261605. Epub 2023 Sep 23.
Thirty-four phytochemicals were isolated from dry tubers of Rchb.f. The compounds were classified as bibenzyls -, dihydrophenanthrenes , , , , phenanthrenes , , , simple benzoids -, a fatty acid , glucosyloxybenzyl 2-isobutylmalates -, and glucosyloxybenzyl cinnamates , . Compounds -, , , , , and inhibited melanogenesis (17.96-55.27%) induced by α-MSH in B16F10 cells at 10-40 μM. However, compounds , , , , and exhibited significant cytotoxicity against melanomas, with IC values of 12-34 μM. Additionally, compounds , , , , , , and reduced the ROS generation induced by HO in HaCaT cells at 6.25-100 μM. In particular, compounds , , and strongly inhibited ROS generation, with IC values of 2.15-9.48 μM. Consequently, compounds -, -, and - may be the strongest leads to follow in extract for further research on the skin disorders, hyperpigmentation, melanoma, and ageing.
从 Rchb.f 的干块茎中分离得到 34 种植物化学物质。这些化合物被分类为联苯，二氢菲，菲，，，，菲，，，简单苯并，脂肪酸，葡萄糖氧基苄基 2-异丁基苹果酸酯，和葡萄糖氧基苄基肉桂酸酯，。化合物 -，-，-，-，-和-在 10-40 μM 时抑制 α-MSH 在 B16F10 细胞中诱导的黑色素生成（17.96-55.27％）。然而，化合物-，-，-，-和-对黑色素瘤表现出显著的细胞毒性，IC 值为 12-34 μM。此外，化合物-，-，-，-，-，-和-在 6.25-100 μM 时降低了 HO 在 HaCaT 细胞中诱导的 ROS 生成。特别是，化合物-，-和-强烈抑制 ROS 生成，IC 值为 2.15-9.48 μM。因此，化合物-，-和-可能是从 提取物中进一步研究皮肤疾病、色素沉着过度、黑色素瘤和衰老的最强先导化合物。
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