白及块茎中的抗菌成分。
Antimicrobial constituents from the tubers of Bletilla ochracea.
机构信息
College of Pharmacy, South-Central University for Nationalities, Wuhan, P. R. China.
出版信息
Planta Med. 2012 Apr;78(6):606-10. doi: 10.1055/s-0031-1298264. Epub 2012 Mar 1.
A new 2-(2-methylpropyl)butanedioic acid derivative, bletillin A ( 1), and a new bibenzyl, bletillin B ( 2), together with seventeen known compounds ( 3- 19), were isolated from the tubers of Bletilla ochracea Schltr. Their structures were established by detailed spectroscopic analyses. Phenanthrenes ( 12- 14) exhibited antibacterial activities against gram-positive bacteria Staphylococcus aureus, S. epidermidis, and Bacillus subtilis, with MIC values of 12.5-25 µg/mL.
从白及块茎中分离得到一个新的 2-(2-甲基丙基)丁二酸衍生物 bletillin A (1) 和一个新的联苄，bletillin B (2)，以及十七个已知化合物(3-19)。通过详细的光谱分析确定了它们的结构。菲类化合物(12-14)对革兰氏阳性菌金黄色葡萄球菌、表皮葡萄球菌和枯草芽孢杆菌具有抗菌活性，MIC 值为 12.5-25μg/mL。
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