Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, USA.
Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, USA; Center for Research on Ingredient Safety, Michigan State University, East Lansing, MI, USA.
Food Chem Toxicol. 2019 Nov;133:110793. doi: 10.1016/j.fct.2019.110793. Epub 2019 Aug 29.
The toxicity of dietary E 171, a food grade titanium dioxide was evaluated. A recent study reported rats receiving E 171 in water developed inflammation and aberrant crypt foci (ACF) in the gastrointestinal tract. Here, rats received food containing E 171 (7 or 100 days). The 100-day study included feeding E 171 after dimethylhydrazine (DMH) or vehicle only pretreatment. Food consumption was similar between treatment groups with maximum total cumulative E 171 exposure being 2617 mg/kg in 7 days and 29,400 mg/kg in 100 days. No differences were observed due to E 171 in the percentage of dendritic, CD4 T or T cells within Peyer's patches or the periphery, or in cytokine production in plasma, sections of jejunum, and colon in 7- or 100-day E 171 alone fed rats. Differences were observed for IL-17A in colon (400 ppm E 171 + DMH) and IL-12p70 in plasma (40 ppm E 171 + DMH). E 171 had no effect on histopathologic evaluations of small and large intestines, liver, spleen, lungs, or testes, and no effects on ACF, goblet cell numbers, or colonic gland length. Dietary E 171 administration (7- or 100-day), even at high doses, produced no effect on the immune parameters or tissue morphology.
食品级二氧化钛 E171 的毒性进行了评估。最近的一项研究报告称，饮用水中摄入 E171 的大鼠在胃肠道中出现了炎症和异常隐窝病灶（ACF）。在这里，大鼠接受了含有 E171 的食物（7 天或 100 天）。100 天的研究包括在给予 E171 之前用二甲基肼（DMH）或仅载体预处理。各组大鼠的食物消耗量相似，在 7 天内，E171 的最大总累积暴露量为 2617mg/kg，而在 100 天内为 29400mg/kg。在 7 天或 100 天单独给予 E171 的大鼠中，Peyer's 斑或外周血中树突状细胞、CD4T 细胞或 T 细胞的百分比，或细胞因子在血浆、空肠和结肠中的产生，均未因 E171 而出现差异。在结肠（400ppmE171+DMH）和血浆（40ppmE171+DMH）中观察到了白细胞介素-17A（IL-17A）和白细胞介素-12p70（IL-12p70）的差异。E171 对大小肠、肝脏、脾脏、肺或睾丸的组织病理学评估没有影响，也对 ACF、杯状细胞数量或结肠腺长度没有影响。即使在高剂量下，E171 经口给予（7 天或 100 天）也不会影响免疫参数或组织形态。
