Cheng Ce, Wu Zhihua, McClements David Julian, Zou Liqiang, Peng Shengfeng, Zhou Wei, Liu Wei
State Key Laboratory of Food Science and Technology, Nanchang University, No. 235 Nanjing East Road, Nanchang 330047, Jiangxi, China.
Biopolymers & Colloids Research Laboratory, Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA.
Colloids Surf B Biointerfaces. 2019 Nov 1;183:110460. doi: 10.1016/j.colsurfb.2019.110460. Epub 2019 Aug 26.
A novel cholesterol-free curcumin delivery system was fabricated by rhamnolipids modified liposomes (RL-Lps). The incorporation of the rhamnolipids increased the sphericity, reduced the size, and decreased the polydispersity of the liposomes compared with pure liposomes (Lps). Analysis of the environmental stability of the RL-Lps showed they have good long-term stability over a wide range of pH (2-3 and 5-8), ionic strengths (0-200 mM), and accelerated centrifugal conditions. The curcumin-loaded rhamnolipids modified liposomes (Cur-RL-Lps) could be prepared with a relatively high loading efficiency (LE > 90%) and loading capacity (LC > 3.5%). The thermal and photochemical stability of the curcumin was improved after encapsulation in the Cur-RL-Lps. In vitro release studies indicated that the sustained release of the curcumin was prolonged when rhamnolipids were incorporated into the liposomes. This study shows that rhamnolipids have great potential for liposomal delivery system suitable for utilization in functional foods, dietary supplements, and pharmaceutical preparations.
一种新型的无胆固醇姜黄素递送系统由鼠李糖脂修饰的脂质体（RL-Lps）制备而成。与纯脂质体（Lps）相比，鼠李糖脂的掺入增加了脂质体的球形度，减小了其尺寸，并降低了多分散性。对RL-Lps的环境稳定性分析表明，它们在广泛的pH范围（2 - 3和5 - 8）、离子强度（0 - 200 mM）以及加速离心条件下具有良好的长期稳定性。负载姜黄素的鼠李糖脂修饰脂质体（Cur-RL-Lps）可以以相对较高的负载效率（LE > 90%）和负载量（LC > 3.5%）制备。姜黄素包封在Cur-RL-Lps中后，其热稳定性和光化学稳定性得到了提高。体外释放研究表明，当鼠李糖脂掺入脂质体中时，姜黄素的持续释放时间延长。这项研究表明，鼠李糖脂在适用于功能性食品、膳食补充剂和药物制剂的脂质体递送系统中具有巨大潜力。
