Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Region Västra Götaland, Sahlgrenska University Hospital, Neurology Clinic, Gothenburg, Sweden.
BMJ Open. 2019 Aug 30;9(8):e029147. doi: 10.1136/bmjopen-2019-029147.
To examine the longitudinal relationship between cardiovascular fitness in young adult men and future risk of migraine and to estimate eventual differential effects among categories of body mass index (BMI) and blood pressure.
National, prospective, population-based cohort study.
Sweden 1968-2014.
18-year-old Swedish men (n=1 819 828) who underwent mandatory military conscription examinations during the years 1968-2005.
The primary outcome was the first dispensation of prescribed migraine-specific medication, identified using the Swedish Prescribed Drug Register. The secondary outcome was documented migraine diagnosis from the Swedish National Hospital Register.
During follow-up, 22 533 men filled a prescription for migraine-specific medication. After confounding adjustment, compared with high cardiovascular fitness, low and medium fitness increased the risk of migraine-specific medication (risk ratio (RR): 1.29, 95% CI 1.24 to 1.35; population attributable fraction: 3.6%, 95% CI 1.7% to 5.3% and RR: 1.15, 95% CI 1.12 to 1.19; population attributable fraction: 8.0%, 95% CI 4.0% to 11.7%). To assess potential effect measure modification, stratified analyses of these association by levels of BMI and blood pressure showed that lower fitness levels increased risk of migraine across all groups except among underweight men or men with high diastolic blood pressure.
Young men with a lower cardiovascular fitness had a higher long-term risk of developing pharmacological prescription-requiring migraine. This study contributes with information regarding risk factors for migraine in men, an understudied population in migraine research.
探讨年轻男性心血管健康与未来偏头痛风险之间的纵向关系，并估计体重指数（BMI）和血压分类下的潜在差异影响。
全国性、前瞻性、基于人群的队列研究。
瑞典，1968-2014 年。
1968-2005 年间参加瑞典兵役体检的 18 岁男性（n=1819828 人）。
主要结局是使用瑞典处方药物登记处确定的首次开出偏头痛专用药物。次要结局是从瑞典国家医院登记处记录的偏头痛诊断。
随访期间，22533 名男性开出了偏头痛专用药物的处方。在混杂因素调整后，与心血管健康高的人群相比，心血管健康低和中等的人群偏头痛专用药物的风险增加（风险比（RR）：1.29，95%置信区间（CI）1.24 至 1.35；人群归因分数：3.6%，95%CI 1.7%至 5.3%和 RR：1.15，95%CI 1.12 至 1.19；人群归因分数：8.0%，95%CI 4.0%至 11.7%）。为了评估潜在的效应修正，根据 BMI 和血压水平对这些关联进行分层分析表明，除了体重不足的男性或舒张压高的男性外，较低的健康水平增加了偏头痛的风险。
心血管健康较低的年轻男性发生需要药物治疗的偏头痛的长期风险更高。这项研究为男性偏头痛的危险因素提供了信息，这是偏头痛研究中一个研究不足的人群。
