Ornello Raffaele, Ripa Patrizia, Pistoia Francesca, Degan Diana, Tiseo Cindy, Carolei Antonio, Sacco Simona
Department of Applied Clinical Sciences and Biotechnology, Institute of Neurology, University of L'Aquila, 67100, L'Aquila, Italy.
J Headache Pain. 2015 Mar 28;16:27. doi: 10.1186/s10194-015-0510-z.
Several studies have assessed the associations between migraine and underweight, pre-obesity or obesity, with conflicting results. To assess the consistency of the data on the topic, we performed a systematic review and meta-analysis of the available observational studies.
Multiple electronic databases were systematically searched up to October 2014 for studies assessing the association between migraine and body mass index categories (underweight, pre-obesity, or obesity).
Out of 2,022 records, we included 15 studies. When considering the 11 studies following the World Health Organization BMI cutoffs, we found an increased risk of having migraine in underweight subjects (pooled adjusted effect estimate [PAEE] 1.21; 95% CI, 1.07-1.37; P = 0.002) and in obese women (PAEE 1.44; 95% CI, 1.05-1.97; P = 0.023) as compared with normal weight subjects; additionally, pre-obese subjects had an increased risk of having chronic migraine (PAEE 1.39; 95% CI, 1.13-1.71; P = 0.002). When considering all the 15 studies, we additionally found an increased risk of having migraine in obese as compared with normal weight subjects (PAEE 1.14; 95% CI, 1.02-1.27; P = 0.017); additionally, obese subjects had an increased risk of having chronic migraine (PAEE 1.75; 95% CI, 1.33-2.29; P < 0.001). The pooled analysis did not indicate an increased risk of having migraine in pre-obese subjects.
The meta-analysis of the available observational studies suggested an association between migraine and obesity likely mediated by gender and migraine frequency. Further studies taking into account gender, migraine type, frequency, activity, and duration could provide more robust evidence.
多项研究评估了偏头痛与体重过轻、肥胖前期或肥胖之间的关联，但结果相互矛盾。为评估该主题数据的一致性，我们对现有的观察性研究进行了系统评价和荟萃分析。
截至2014年10月，系统检索多个电子数据库，以查找评估偏头痛与体重指数类别（体重过轻、肥胖前期或肥胖）之间关联的研究。
在2022条记录中，我们纳入了15项研究。在考虑遵循世界卫生组织体重指数临界值的11项研究时，我们发现与正常体重受试者相比，体重过轻的受试者患偏头痛的风险增加（合并调整效应估计值[PAEE]为1.21；95%置信区间，1.07 - 1.37；P = 0.002），肥胖女性患偏头痛的风险增加（PAEE为1.44；95%置信区间，1.05 - 1.97；P = 0.023）；此外，肥胖前期受试者患慢性偏头痛的风险增加（PAEE为1.39；95%置信区间，1.13 - 1.71；P = 0.002）。在考虑所有15项研究时，我们还发现与正常体重受试者相比，肥胖者患偏头痛的风险增加（PAEE为1.14；95%置信区间，1.02 - 1.27；P = 0.017）；此外，肥胖受试者患慢性偏头痛的风险增加（PAEE为1.75；95%置信区间，1.33 - 2.29；P < 0.001）。汇总分析未表明肥胖前期受试者患偏头痛的风险增加。
对现有观察性研究的荟萃分析表明，偏头痛与肥胖之间可能存在关联，这种关联可能由性别和偏头痛发作频率介导。进一步考虑性别、偏头痛类型、发作频率、活动和持续时间的研究可能会提供更有力的证据。
