Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg,Gothenburg,Sweden.
Department of Primary Health Care,Institute of Medicine, Sahlgrenska Academy, University of Gothenburg,Gothenburg,Sweden.
Psychol Med. 2018 Feb;48(3):416-425. doi: 10.1017/S0033291717001763. Epub 2017 Jun 28.
Cardiovascular fitness in late adolescence is associated with future risk of depression. Relationships with other mental disorders need elucidation. This study investigated whether fitness in late adolescence is associated with future risk of serious non-affective mental disorders. Further, we examined how having an affected brother might impact the relationship.
Prospective, population-based cohort study of 1 109 786 Swedish male conscripts with no history of mental illness, who underwent conscription examinations at age 18 between 1968 and 2005. Cardiovascular fitness was objectively measured at conscription using a bicycle ergometer test. During the follow-up (3-42 years), incident cases of serious non-affective mental disorders (schizophrenia and schizophrenia-like disorders, other psychotic disorders and neurotic, stress-related and somatoform disorders) were identified through the Swedish National Hospital Discharge Register. Cox proportional hazards models were used to assess the influence of cardiovascular fitness at conscription and risk of serious non-affective mental disorders later in life.
Low fitness was associated with increased risk for schizophrenia and schizophrenia-like disorders [hazard ratio (HR) 1.44, 95% confidence interval (CI) 1.29-1.61], other psychotic disorders (HR 1.41, 95% CI 1.27-1.56), and neurotic or stress-related and somatoform disorders (HR 1.45, 95% CI 1.37-1.54). Relationships persisted in models that included illness in brothers.
Lower fitness in late adolescent males is associated with increased risk of serious non-affective mental disorders in adulthood.
青少年晚期的心血管健康与未来患抑郁症的风险相关。与其他精神障碍的关系尚待阐明。本研究旨在调查青少年晚期的健康状况是否与未来严重非情感性精神障碍的风险相关。此外，我们还研究了受影响兄弟的存在可能如何影响这种关系。
这是一项前瞻性、基于人群的队列研究，共纳入了 1109786 名瑞典男性应征者，他们在 1968 年至 2005 年间没有精神疾病史，在 18 岁时接受了兵役检查。心血管健康在兵役检查时使用自行车测力计测试进行客观测量。在随访期间（3-42 年），通过瑞典国家住院登记处确定严重非情感性精神障碍（精神分裂症和精神分裂症样障碍、其他精神病性障碍以及神经症、应激相关和躯体形式障碍）的发病情况。使用 Cox 比例风险模型评估兵役时心血管健康状况对晚年严重非情感性精神障碍风险的影响。
低健康水平与精神分裂症和精神分裂症样障碍（风险比 1.44，95%置信区间 1.29-1.61）、其他精神病性障碍（风险比 1.41，95%置信区间 1.27-1.56）以及神经症、应激相关和躯体形式障碍（风险比 1.45，95%置信区间 1.37-1.54）的风险增加相关。在包括兄弟患病的模型中，这些关系仍然存在。
青少年晚期男性的健康水平较低与成年后严重非情感性精神障碍的风险增加相关。
