Pop-Vicas Aurora, Safdar Nasia
Division of Infectious Disease, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Division of Infectious Disease, University of Wisconsin Hospitals and Clinics, 1685 Highland Avenue, 5th floor, Madison, WI, 53705, USA.
Curr Infect Dis Rep. 2019 Aug 31;21(10):35. doi: 10.1007/s11908-019-0692-7.
To identify the most common strategies currently used for S. aureus decolonization and surgical site infection (SSI) prevention.
Pre-operative colonization with Staphylococcus aureus increases SSI risk. Screening and decolonization with intra-nasal mupirocin and pre-operative chlorhexidine bathing remains the most common and effective strategy, especially for orthopedic and cardiovascular surgery. Intra-nasal povidone-iodine immediately before surgery appears effective in preliminary studies, is less expensive, and may be easier to implement in the clinical setting. Future well-designed clinical research studies are needed to confirm its effectiveness in SSI prevention. Intra-nasal alcohol-based antisepsis and photodynamic therapy are promising strategies that deserve further study before they can be clinically applied to SSI prevention. Decolonization with intra-nasal mupirocin or povidone-iodine, in addition to pre-operative chlorhexidine bathing, is an important SSI prevention strategy. Future studies should address optimal dosing, timing, and number of applications for each regimen.
确定目前用于金黄色葡萄球菌去定植和预防手术部位感染（SSI）的最常见策略。
术前金黄色葡萄球菌定植会增加SSI风险。鼻内使用莫匹罗星进行筛查和去定植以及术前洗必泰沐浴仍然是最常见且有效的策略，尤其是在骨科和心血管手术中。术前立即使用鼻内聚维酮碘在初步研究中似乎有效，成本更低，并且在临床环境中可能更易于实施。未来需要精心设计的临床研究来证实其在预防SSI方面的有效性。鼻内酒精基防腐和光动力疗法是有前景的策略，在临床应用于预防SSI之前值得进一步研究。除术前洗必泰沐浴外，鼻内使用莫匹罗星或聚维酮碘去定植是预防SSI的重要策略。未来的研究应探讨每种方案的最佳剂量、时间和应用次数。
