Hammond Eric N, Kates Ashley E, Putman-Buehler Nathan, Watson Lauren, Godfrey Jared J, Riley Colleen N, Dixon Jonah, Brys Nicole, Haleem Ambar, Bentz Michael L, Safdar Nasia
Institute for Clinical and Translational Research, University of Wisconsin-Madison, Madison, WI, 53705, USA.
Division of Infectious Disease, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.
Infect Prev Pract. 2023 Feb 18;5(2):100274. doi: 10.1016/j.infpip.2023.100274. eCollection 2023 Jun.
Surgical site infection prevention and treatment remains a challenge in healthcare settings globally. The routine use of intranasal mupirocin for decolonization has challenges and preoperative intranasal povidone-iodine decolonization is another option. The purpose of this quality improvement study was to assess if a one-time preoperative intranasal povidone-iodine application could reduce the risk of the likelihood of nasal carriage of after surgery.
Ambulatory Surgery Center patients were enrolled in an intranasal povidone-iodine decolonization quality improvement study as they reported at the pre-operative holding area. Pre-decolonization intranasal samples were collected, followed by intranasal application of povidone-iodine. Patients waited for a minimum of 20 minutes after application before proceeding with surgery. Nasal samples were again collected after surgery. Each sample was tested for colonization using the 16S rRNA-mecA-nuc triplex polymerase chain reaction, standard biochemical tests, and qualitative culturing.
In the 98 patients enrolled, 36% of these patients had intranasal colonization with by 16S rRNA-mecA-nuc triplex polymerase chain reaction before surgery. Using a qualitative culture technique, 28% of patients tested positive for before surgery and 20% of patients tested positive for after surgery ( = 0.039).
Intranasal preoperative povidone-iodine is an effective strategy in the decolonization of from the nares if properly implemented.
手术部位感染的预防和治疗在全球医疗环境中仍然是一项挑战。常规使用鼻内莫匹罗星进行去定植存在挑战，术前鼻内应用聚维酮碘去定植是另一种选择。这项质量改进研究的目的是评估术前一次性鼻内应用聚维酮碘是否可以降低术后鼻腔携带[具体细菌名称未给出]的风险。
门诊手术中心的患者在术前等候区报到时被纳入鼻内聚维酮碘去定植质量改进研究。在去定植前采集鼻内样本，随后鼻内应用聚维酮碘。患者应用后等待至少20分钟再进行手术。术后再次采集鼻内样本。每个样本使用16S rRNA - mecA - nuc三重聚合酶链反应、标准生化试验和定性培养检测[具体细菌名称未给出]定植情况。
在纳入的98例患者中，术前通过16S rRNA - mecA - nuc三重聚合酶链反应检测，36%的患者鼻内有[具体细菌名称未给出]定植。使用定性培养技术，术前28%的患者检测[具体细菌名称未给出]呈阳性，术后20%的患者检测[具体细菌名称未给出]呈阳性（P = 0.039）。
如果正确实施，术前鼻内应用聚维酮碘是从鼻腔去除[具体细菌名称未给出]定植的有效策略。
