Center for Eating Disorders, Odense University Hospital, Odense, Denmark.
Endocrine Research Unit, Odense University Hospital, Odense, Denmark.
Eat Weight Disord. 2020 Oct;25(5):1347-1355. doi: 10.1007/s40519-019-00769-7. Epub 2019 Aug 31.
Appetite is a subjective essential sense. In patients with severe anorexia nervosa (AN), controversy remains whether this sensation is altered. The objectives were to clarify, in patients with severe AN: (1) Whether the appetite changes during partial weight restoration, (2) Whether potential changes in appetite are related to (i) diagnostic subtype of AN, (ii) psychopharmacological treatment, (iii) disease duration, (iv) duration of hospitalization, and (v) baseline body mass index (BMI).
The study consisted of 39 patients, with a mean age of 23.7 ± 8 and an admission mean BMI of 13.1 ± 2.0 kg/m. The patients were consecutively admitted to a specialized somatic nutrition unit between 2015 and 2016. They were asked to rate their hunger and satiety on a numeric visual analog scale (VAS), before and after a lunch meal at admission and at discharge in the same standardized environment. The patients could participate more than once if readmitted, resulting in a total of 119 observed meals. Data were analyzed in a regression model for repeated measures.
At admission, changes in hunger and satiety perception were weak. After weight gain of 10.4% ± 8.5% within a median of 26 (IQR: 25) days, there was a slight increase in hunger perception, p = 0.049. However, there was no detectable change in satiety perception. There was no noticeable correlation between appetite change and psychopharmacological treatment, diagnostic subtype, BMI, duration of hospitalization, and disease duration.
Hospitalized patients with severe AN exhibit strikingly weak changes in hunger and satiety perception during standardized and supervised meals.
Level IV, evidence obtained from multiple time series analysis.
食欲是一种主观的基本感觉。在严重神经性厌食症（AN）患者中，这种感觉是否改变仍存在争议。本研究旨在明确以下内容：（1）在部分体重恢复期间，患者的食欲是否发生变化；（2）食欲的潜在变化是否与以下因素相关：i）AN 的诊断亚型，ii）精神药理学治疗，iii）疾病持续时间，iv）住院时间，以及 v）基线体重指数（BMI）。
该研究纳入了 39 名患者，平均年龄为 23.7±8 岁，入院时平均 BMI 为 13.1±2.0kg/m。这些患者于 2015 年至 2016 年连续入住一家专门的躯体营养病房。在入院时和相同的标准化环境下出院前，患者被要求使用数字视觉模拟量表（VAS）评估他们的饥饿感和饱腹感。如果患者再次入院，他们可以多次参与，共观察到 119 次进餐。数据采用重复测量回归模型进行分析。
入院时，饥饿感和饱腹感的变化较弱。在中位数为 26 天（IQR：25）内体重增加 10.4%±8.5%后，饥饿感略有增加，p=0.049。然而，饱腹感并没有明显变化。食欲变化与精神药理学治疗、诊断亚型、BMI、住院时间和疾病持续时间之间没有明显的相关性。
住院的严重 AN 患者在标准化和监督的进餐过程中，饥饿感和饱腹感的变化非常微弱。
IV 级，来源于多个时间序列分析的证据。
