Department of Tissue and Organ Development, Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine.
General Research & Development Institute, Hoyu Co., Ltd.
Biol Pharm Bull. 2019;42(9):1446-1449. doi: 10.1248/bpb.b19-00295.
During the process of skin regeneration following a skin injury, de novo hair follicle regeneration is initiated after wounding; however, these regenerated hairs are mostly unpigmented. The activation of epidermal melanocyte stem cells and their differentiation into regenerating hair follicles have been shown to be necessary for the pigmented hair regeneration after wounding. To determine the role of flavonoids in the regeneration of pigmented hairs, we applied the candidate flavonoids to the regenerating hair follicles after wounding and identified the flavonoid species that maximally induced pigmented hair regeneration. Flavonoids with two OH groups in the B-ring, such as sterubin, luteolin, and hydroxygenkwanin, showed promising effects in regenerating black pigmented hairs, while those with one OH group in the B-ring showed no significant change. Thus, flavonoids with two OH groups in their B-ring could be studied further as potential wound healing agents with the ability to regenerate pigmented hair.
在皮肤损伤后的皮肤再生过程中，创伤后会启动新的毛囊再生；然而，这些再生的毛发大多没有色素。表皮黑素细胞干细胞的激活及其分化为再生毛囊已被证明是创伤后色素性毛发再生所必需的。为了确定类黄酮在色素性毛发再生中的作用，我们在创伤后将候选类黄酮应用于再生的毛囊中，并确定了最大程度诱导色素性毛发再生的类黄酮种类。B 环中带有两个 OH 基团的类黄酮，如 Sterubin、Luteolin 和 Hydroxygenkwanin，在再生黑色色素性毛发方面表现出良好的效果，而 B 环中带有一个 OH 基团的类黄酮则没有明显变化。因此，B 环中带有两个 OH 基团的类黄酮可以作为具有再生色素性毛发能力的潜在伤口愈合剂进一步研究。
