基于紫杉叶素的制剂作用下化学烧伤后的皮肤再生

Skin regeneration after chemical burn under the effect of taxifolin-based preparations.

作者信息

Shubina V S, Shatalin Yu V

机构信息

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia.

出版信息

Bull Exp Biol Med. 2012 Nov;154(1):152-7. doi: 10.1007/s10517-012-1897-z.

DOI:10.1007/s10517-012-1897-z

PMID:23330113

Abstract

We studied the effect of liposome preparation containing taxifolin oligomers and taxifolin conjugates with carbonyl compounds on skin regeneration after chemical burn. The preparations containing flavonoid conjugates intensified regeneration processes and reparation of hair follicles and sebaceous glands after chemical burn. The preparation based on taxifolin conjugate with acetaldehyde was most effective; its activity was comparable with that of the wound-healing preparation Olasol. Taxifolin conjugates with carbonyl compounds can be used for the creation of combined wound- and burn-healing preparations.

摘要

我们研究了含有花旗松素低聚物以及花旗松素与羰基化合物共轭物的脂质体制剂对化学烧伤后皮肤再生的影响。含有类黄酮共轭物的制剂可强化化学烧伤后毛囊和皮脂腺的再生过程及修复。基于花旗松素与乙醛共轭物的制剂最为有效；其活性与伤口愈合制剂奥拉索尔相当。花旗松素与羰基化合物的共轭物可用于制备联合伤口和烧伤愈合制剂。