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安慰剂反应的神话。

The Myth of the Placebo Response.

作者信息

Jonas Wayne B

机构信息

Samueli Integrative Health Programs, Alexandria, VA, United States.

Georgetown University School of Medicine, Washington, DC, United States.

出版信息

Front Psychiatry. 2019 Aug 16;10:577. doi: 10.3389/fpsyt.2019.00577. eCollection 2019.

Abstract

The placebo response is a myth. It does not exist in reality, and continuing to name it is hindering the optimal application of science to healing in medicine. On the surface, it is obvious that, when defined as a biological response to an inert pill (like a sugar pill), the idea of a "response" to a placebo is impossible. Inert treatments by definition do not produce responses. So why do we continue to ponder why people get better from taking inert substances and base our acceptance of legitimate treatments on demonstrating that they go beyond that response? The problem arises because we have flawed assumptions of the value that reductionistic science and the demonstration of specific effects has for healing. To support those flawed assumptions, we support the idea of "the placebo response." This causes confusion among patients, clinicians, regulators, and even scientists. Legitimate medical treatments have become defined as those that do more than produce a placebo response. An entire pharmaceutical industry and its regulators attempt to control and profit by proving that small molecules produce a clinical effect greater than the placebo response. Billions of dollars are made when that is proven, often even when the size of the response in the active over the placebo group is miniscule. The fact is people heal and that inherent healing capacity is both powerful and influenced by mental, social, and contextual factors that are embedded in every medical encounter since the idea of treatment began. In this chapter, I argue that our understanding of healing and ability to enhance it will be accelerated if we stop using the term "placebo response" and call it what it is-the meaning response, and its special application in medicine called the healing response.

摘要

安慰剂反应是个神话。它在现实中并不存在,继续提及它阻碍了科学在医学治疗中的最佳应用。从表面上看,很明显,当把安慰剂定义为对惰性药丸(如糖丸)的生物学反应时,对安慰剂产生“反应”的想法是不可能的。根据定义,惰性治疗不会产生反应。那么,为什么我们还要继续思考为什么人们服用惰性物质后会好转,并将我们对合理治疗的认可建立在证明它们能超越这种反应的基础上呢?问题的出现是因为我们对还原论科学以及特定效应的证明对治疗的价值存在错误的假设。为了支持这些错误的假设,我们支持“安慰剂反应”的观点。这在患者、临床医生、监管机构甚至科学家中都造成了困惑。合理的医学治疗已被定义为那些比产生安慰剂反应效果更好的治疗。整个制药行业及其监管机构试图通过证明小分子产生的临床效果大于安慰剂反应来进行控制并获利。当这一点得到证实时,就能赚取数十亿美元,即便活性药物组与安慰剂组之间的反应差异微乎其微。事实上,人们会自愈,这种内在的自愈能力很强大,并且受到自治疗概念产生以来每次医疗接触中所包含的心理、社会和情境因素的影响。在本章中,我认为,如果我们不再使用“安慰剂反应”这个术语,而是称其为实际的含义反应,以及它在医学中的特殊应用即治愈反应,那么我们对治愈的理解以及增强治愈能力的速度将会加快。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2e9/6707261/821bb8154607/fpsyt-10-00577-g001.jpg

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