Turhan N O, Artini P G, D'Ambrogio G, Droghini F, Battaglia C, Genazzani A D, Volpe A, Genazzani A R
Department of Obstetrics and Gynecology, University of Modena, Italy.
J Assist Reprod Genet. 1993 Jan;10(1):15-20. doi: 10.1007/BF01204435.
This study compares the results of three ovulation induction protocols in polycystic ovarian disease (PCOD) patients undergoing an in vitro fertilization-embryo transfer (IVF-ET) program. A total of 85 cycles was studied. The patients were treated with clomiphene citrate (CC) plus human menopausal gonadotropin (hMG) (CC/hMG group), with purified menofollitropin (pFSH) plus hMG (pFSH/hMG group), and with pFSH/hMG plus gonadotropin releasing hormone analogue (GnRH-a) (analogue group). In the analogue group the suppression of luteinizing hormone (LH) with GnRH-a decreased the number of follicles < 12 mm on the day of human chorionic gonadotropin (hCG) administration and the number and percentage of immature oocytes retrieved and increased the percentage of mature oocytes retrieved.
However, fertilization rates of oocytes, cleaved embryo rates, pregnancy rates following replacement, and pregnancy outcomes were not different.
Although the suppression of the hypothalamic-pituitary-ovarian axis with GnRH-a in PCOD patients improved follicular synchrony and oocyte maturity, none of the ovulation induction protocols was superior to the others with respect to pregnancy rates and pregnancy outcomes.
本研究比较了多囊卵巢疾病（PCOD）患者在体外受精-胚胎移植（IVF-ET）项目中三种促排卵方案的结果。共研究了85个周期。患者分别接受枸橼酸氯米芬（CC）加人绝经期促性腺激素（hMG）治疗（CC/hMG组）、纯化卵泡刺激素（pFSH）加hMG治疗（pFSH/hMG组）以及pFSH/hMG加促性腺激素释放激素类似物（GnRH-a）治疗（类似物组）。在类似物组中，GnRH-a对黄体生成素（LH）的抑制作用减少了人绒毛膜促性腺激素（hCG）给药当天直径<12mm的卵泡数量、回收的未成熟卵母细胞数量和百分比，并增加了回收的成熟卵母细胞百分比。
然而，卵母细胞的受精率、分裂胚胎率、移植后的妊娠率和妊娠结局并无差异。
尽管GnRH-a对PCOD患者下丘脑-垂体-卵巢轴的抑制作用改善了卵泡同步性和卵母细胞成熟度，但在妊娠率和妊娠结局方面，没有一种促排卵方案优于其他方案。
