Van Etten Emily J, Graves Lisa V, Taylor Brad, Holden Heather M, Lopez Francesca V, Williams McKenna E, Pirogovsky-Turk Eva, Corey-Bloom Jody, Filoteo J Vincent, Delis Dean C, Gilbert Paul E
Department of Psychology, San Diego State University, San Diego, CA, USA.
San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego/La Jolla, CA, USA.
J Huntingtons Dis. 2019;8(4):459-465. doi: 10.3233/JHD-190346.
Parkinson's disease (PD) and Huntington's disease (HD) are two neurodegenerative diseases affecting frontal-striatal function and memory ability. Studies using the original California Verbal Learning Test (CVLT) to examine recall and recognition abilities between these groups have produced mixed findings. Some found that individuals with HD demonstrate worse recall and recognition than those with PD, whereas others reported comparable performance.
We utilized multiple indices of recall and recognition discriminability, provided by the second and third editions of the CVLT (CVLT-II and CVLT-3, respectively), that allow for a more thorough assessment of more nuanced aspects of verbal memory function.
We examined differences between individuals with PD (n = 72) and those with HD (n = 77) on CVLT-II indices of recall discriminability (immediate, short delay free and cued, long delay free and cued) and recognition discriminability (total, source, semantic, and novel) using standardized scores while controlling for education and Dementia Rating Scale-2 scores.
The HD group performed significantly worse than the PD group on all measures of recall and recognition discriminability (ps < 0.05), and group differences were associated with large Cohen's d effect sizes.
Our findings suggest that individuals with HD are more impaired than individuals with PD in more nuanced aspects of recall and recognition memory function. These CVLT indices yield more thorough assessments of recall and recognition memory function and have the potential to improve efforts to characterize and distinguish profiles of memory loss in different neurodegenerative populations, including PD and HD.
帕金森病（PD）和亨廷顿舞蹈病（HD）是两种影响额叶 - 纹状体功能和记忆能力的神经退行性疾病。使用原始的加利福尼亚言语学习测验（CVLT）来检查这些群体之间回忆和识别能力的研究结果不一。一些研究发现，HD患者的回忆和识别能力比PD患者差，而另一些研究则报告两者表现相当。
我们利用CVLT第二版和第三版（分别为CVLT - II和CVLT - 3）提供的回忆和识别辨别力的多个指标，以便更全面地评估言语记忆功能的更细微方面。
我们使用标准化分数，在控制教育程度和痴呆评定量表 - 2分数的同时，检查了PD患者（n = 72）和HD患者（n = 77）在CVLT - II回忆辨别力指标（即时、短延迟自由回忆和线索回忆、长延迟自由回忆和线索回忆）和识别辨别力指标（总体、来源、语义和新颖性）上的差异。
HD组在所有回忆和识别辨别力测量指标上的表现均显著低于PD组（p < 0.05），且组间差异与较大的科恩d效应量相关。
我们的研究结果表明，在回忆和识别记忆功能的更细微方面，HD患者比PD患者受损更严重。这些CVLT指标能更全面地评估回忆和识别记忆功能，并有潜力改善对不同神经退行性疾病群体（包括PD和HD）记忆丧失特征的描述和区分。
