Department of Psychology, California State University San Marcos, San Marcos, CA, USA.
Department of Psychology, San Diego State University, San Diego, CA, USA.
Appl Neuropsychol Adult. 2024 Nov-Dec;31(6):1163-1168. doi: 10.1080/23279095.2022.2112682. Epub 2022 Aug 19.
Research suggests that individuals with Huntington's disease (HD) perform better than individuals with Alzheimer's disease (AD) on the California Verbal Learning Test (CVLT) Yes/No Recognition trial. However, those with HD have been shown to have deficits comparable to those with AD on the Source Recognition Discriminability (RD) index (which assesses the ability to distinguish between List A targets and List B distractors), suggesting that HD may involve selective impairment in aspects of yes/no recognition that rely on source memory. However, whether individuals with HD and AD show comparable deficits on Source RD across stages of dementia severity has not been adequately investigated. We examined performance on the CVLT-3 List A vs. List B RD index in individuals with HD or AD and mild or moderate dementia. Among individuals with mild dementia, scores were higher in the HD versus AD group, whereas among individuals with moderate dementia, scores were comparable between the HD and AD groups; this corresponded to differential performance across dementia stages among individuals with HD, but not AD. The present findings suggest that, relative to AD, HD may be associated with disproportionate decline in aspects of yes/no recognition that rely on source memory.
研究表明，在加利福尼亚语言学习测试（CVLT）的“是/否”识别试验中，亨廷顿病（HD）患者的表现优于阿尔茨海默病（AD）患者。然而，已有研究表明，HD 患者在源识别辨别力（RD）指数上与 AD 患者存在相当的缺陷（该指数评估区分列表 A 目标和列表 B 干扰项的能力），这表明 HD 可能涉及对源记忆依赖的“是/否”识别方面的选择性损伤。然而，HD 和 AD 患者在不同痴呆严重程度阶段的源 RD 上是否表现出类似的缺陷尚未得到充分研究。我们检查了轻度或中度痴呆患者中 HD 或 AD 患者在 CVLT-3 列表 A 与列表 B RD 指数上的表现。在轻度痴呆患者中，HD 组的分数高于 AD 组，而在中度痴呆患者中，HD 组和 AD 组的分数相当；这对应于 HD 患者在不同痴呆阶段的不同表现，但 AD 患者没有。目前的研究结果表明，与 AD 相比，HD 可能与源记忆依赖的“是/否”识别方面的不成比例下降有关。
