Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Université de Lyon, Centre Léon Bérard, Lyon, France.
Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Université de Lyon, Centre Léon Bérard, Lyon, France.
Mech Ageing Dev. 2019 Oct;183:111131. doi: 10.1016/j.mad.2019.111131. Epub 2019 Aug 30.
Cellular senescence is a response characterized by a stable cell proliferation arrest and a senescence-associated secretory phenotype (SASP) which can be induced by many stresses, including telomere shortening and oncogene activation. Senescence is crucially involved in a variety of physiopathological contexts, such as cancer and aging. Given the fundamental role of this process, senescence needs to be tightly regulated. In the last decade, the key implication of nuclear receptors in cellular senescence has emerged. Here we will review the mechanisms involved in the control of cellular senescence by retinoid X receptors (RXRs) and their partners. We will also present our current knowledge on the regulation of these receptors during senescence and on their potential role in senescence-associated physiopathological conditions.
细胞衰老（Cellular senescence）是一种以稳定的细胞增殖停滞和衰老相关分泌表型（SASP）为特征的反应，它可以由多种应激诱导，包括端粒缩短和癌基因激活。衰老（Senescence）在多种生理病理情况下起着至关重要的作用，如癌症和衰老。鉴于这个过程的基础性作用，衰老（Senescence）需要被严格调控。在过去的十年中，核受体在细胞衰老（Cellular senescence）中的关键作用已经显现出来。在这里，我们将回顾视黄酸受体（Retinoid X receptors，RXRs）及其伴侣控制细胞衰老（Cellular senescence）的机制。我们还将介绍我们目前对这些受体在衰老过程中的调节以及它们在与衰老相关的生理病理条件下的潜在作用的了解。
