Centre de Recherche en Cancérologie de Lyon, INSERM U1052, CNRS UMR 5286, Centre Léon Bérard, Equipe Labellisée la Ligue Contre le Cancer, Université de Lyon, Lyon, France.
Centre de Recherche en Cancérologie de Lyon, INSERM U1052, CNRS UMR 5286, Centre Léon Bérard, Equipe Labellisée la Ligue Contre le Cancer, Université de Lyon, Lyon, France.
Cell Calcium. 2023 Mar;110:102701. doi: 10.1016/j.ceca.2023.102701. Epub 2023 Jan 27.
Cellular senescence is a state of stable cell proliferation arrest accompanied by a distinct secretory program impacting the senescent cell microenvironment. This phenotype can be induced by many stresses, including telomere shortening, oncogene activation, oxidative or genotoxic stress. Cellular senescence plays a key role in the organism throughout life, with beneficial effects at a young age for instance in embryonic development and wound healing, and deleterious effects during aging and in aging-related diseases. In the last decade calcium and calcium signaling have been established as critical factors in the implementation and regulation of cellular senescence. In this review we will present and discuss the main discoveries in this field, from the observation of an increased intracellular calcium concentration in senescent cells to the identification of calcium-binding proteins, calcium channels (TRP, ITPR, …) and MERCs (mitochondria-endoplasmic reticulum contact sites) as key players in this context.
细胞衰老是一种稳定的细胞增殖停滞状态，伴随着影响衰老细胞微环境的独特分泌程序。这种表型可以由许多应激诱导，包括端粒缩短、癌基因激活、氧化或遗传毒性应激。细胞衰老在整个生命过程中起着关键作用，年轻时具有有益的影响，例如在胚胎发育和伤口愈合中，而在衰老和与衰老相关的疾病中则具有有害的影响。在过去的十年中，钙和钙信号已被确定为细胞衰老实施和调节的关键因素。在这篇综述中，我们将介绍和讨论该领域的主要发现，从观察到衰老细胞中细胞内钙离子浓度增加到鉴定钙结合蛋白、钙通道（TRP、ITPR 等）和 MERCs（线粒体-内质网接触位点）作为该背景下的关键参与者。
