Wang Lijun, Rohatgi Atharva Piyush, Wan Yu-Jui Yvonne
Department of Pathology and Laboratory Medicine, University of California Davis Health, Sacramento, CA, United States.
Department of Pathology and Laboratory Medicine, University of California Davis Health, Sacramento, CA, United States.
Methods Enzymol. 2020;637:283-308. doi: 10.1016/bs.mie.2020.02.009. Epub 2020 Mar 28.
Retinoic acid (RA), the biologically active metabolite of vitamin A, regulates a vast spectrum of biological processes, such as cell differentiation, proliferation, apoptosis, and morphogenesis. microRNAs (miRNAs) play a crucial role in regulating gene expression by binding to messenger RNA (mRNA) which leads to mRNA degradation and/or translational repression. Like RA, miRNAs regulate multiple biological processes, including proliferation, differentiation, apoptosis, neurogenesis, tumorigenesis, and immunity. In fact, RA regulates the expression of many miRNAs to exert its biological functions. miRNA and RA regulatory networks have been studied in recent years. In this manuscript, we summarize literature that highlights the impact of miRNAs in RA-regulated molecular networks included in the PubMed.
视黄酸（RA）是维生素A的生物活性代谢产物，可调节广泛的生物过程，如细胞分化、增殖、凋亡和形态发生。微小RNA（miRNA）通过与信使核糖核酸（mRNA）结合来调节基因表达，从而导致mRNA降解和/或翻译抑制，在这一过程中发挥着关键作用。与RA一样，miRNA也调节多种生物过程，包括增殖、分化、凋亡、神经发生、肿瘤发生和免疫。事实上，RA通过调节许多miRNA的表达来发挥其生物学功能。近年来，miRNA和RA调控网络已得到研究。在本手稿中，我们总结了文献，这些文献突出了miRNA在PubMed中收录的RA调控分子网络中的影响。
