Nohara Seitaro, Ishii Akiko, Yamamoto Fumiko, Yanagiha Kumi, Moriyama Tetsuya, Tozaka Naoki, Miyake Zenshi, Yatsuga Shuichi, Koga Yasutoshi, Hosaka Takashi, Terada Makoto, Yamaguchi Tetsuto, Aizawa Satoshi, Mamada Naomi, Tsuji Hiroshi, Tomidokoro Yasushi, Nakamagoe Kiyotaka, Ishii Kazuhiro, Watanabe Masahiko, Tamaoka Akira
Department of Neurology, University of Tsukuba, Japan.
Department of Neurology, University of Tsukuba, Japan.
J Neurol Sci. 2019 Oct 15;405:116429. doi: 10.1016/j.jns.2019.116429. Epub 2019 Aug 22.
GDF-15, a member of the transforming growth factor beta superfamily, regulates inflammatory and apoptotic pathways in various diseases, such as heart failure, kidney dysfunction, and cancer. We aimed to clarify potentially confounding variables affecting GDF-15 and demonstrate its utility as a mitochondrial biomarker using serum samples from 15 patients with mitochondrial diseases (MD), 15 patients with limbic encephalitis (LE), 10 patients with multiple sclerosis/neuromyelitis optica spectrum disorders (MS/NMOSD), and 19 patients with amyotrophic lateral sclerosis (ALS). GDF-15 and FGF-21 were significantly elevated in MD. GDF-15 and FGF-21 showed a good correlation in MD but not in LE, MS, and ALS. GDF-15 was potentially influenced by age in LE, MS/NMOSD, and ALS but not in MD. FGF-21 was not correlated with age in MS/NMOSD, ALS, LE, and MD. GDF-15 was not correlated with clinical features in LE or BMI or body weight in ALS. GDF-15 positively correlated with the Expanded Disability Status Scale (EDSS) in MS/NMOSD, while EDSS showed no correlation with age. In conclusion, the results revealed that GDF-15 may be influenced by EDSS in MS/NMOPSD and by age in LE, MS/NMOSD, and ALS but not in MD. Mitochondrial damage in MS/NMOSD is a potentially confounding variable affecting GDF-15.
生长分化因子15（GDF - 15）是转化生长因子β超家族的成员，在多种疾病中调节炎症和凋亡途径，如心力衰竭、肾功能不全和癌症。我们旨在阐明影响GDF - 15的潜在混杂变量，并使用来自15例线粒体疾病（MD）患者、15例边缘性脑炎（LE）患者、10例多发性硬化/视神经脊髓炎谱系障碍（MS/NMOSD）患者和19例肌萎缩侧索硬化症（ALS）患者的血清样本，证明其作为线粒体生物标志物的效用。GDF - 15和FGF - 21在MD患者中显著升高。GDF - 15和FGF - 21在MD患者中显示出良好的相关性，但在LE、MS和ALS患者中未显示出相关性。在LE、MS/NMOSD和ALS患者中，GDF - 15可能受年龄影响，但在MD患者中不受年龄影响。在MS/NMOSD、ALS、LE和MD患者中，FGF - 21与年龄无关。在LE患者中，GDF - 15与临床特征无关，在ALS患者中，GDF - 15与BMI或体重无关。在MS/NMOSD患者中，GDF - 15与扩展残疾状态量表（EDSS）呈正相关，而EDSS与年龄无关。总之，结果表明，GDF - 15在MS/NMOPSD中可能受EDSS影响，在LE、MS/NMOSD和ALS中可能受年龄影响，但在MD中不受影响。MS/NMOSD中的线粒体损伤是影响GDF - 15的一个潜在混杂变量。
