Erlanson-Albertsson C, Larsson A
Department of Medical and Physiological Chemistry, University of Lund, Sweden.
Biochimie. 1988 Sep;70(9):1245-50. doi: 10.1016/0300-9084(88)90191-5.
Pancreatic pro-colipase activation peptide, a pentapeptide with the sequence VPDPR was found to significantly suppress food intake of 20 h fasted Sprague-Dawley rats in a dose-dependent way. A rat treated with pro-colipase-enriched pellets for 26 days showed decreased daily food intake and retarded growth, which were restored during a following period of regular feeding. Genetically obese Zucker rats (fa/fa) were found to contain a reduced content of pancreatic pro-colipase (60% reduction), whereas the pancreatic lipase content was normal. A physiological function of pancreatic pro-colipase activation peptide as an endogenous satiety signal is suggested.
胰腺前脂肪酶激活肽是一种序列为VPDPR的五肽，发现它能以剂量依赖的方式显著抑制禁食20小时的斯普拉格-道利大鼠的食物摄入量。用富含前脂肪酶的颗粒处理26天的大鼠，其每日食物摄入量减少且生长迟缓，在随后的正常喂养期间得以恢复。发现遗传性肥胖的 Zucker 大鼠（fa/fa）胰腺前脂肪酶含量降低（减少60%），而胰腺脂肪酶含量正常。提示胰腺前脂肪酶激活肽作为一种内源性饱腹感信号具有生理功能。
